Results 181 to 190 of about 2,864,901 (314)

Microbiota-Mediated Bile Acid Metabolism as a Mechanistic Framework for Precision Nutrition in Gastrointestinal and Metabolic Diseases. [PDF]

Cells
Kang S, Jeong DY, Seo J, Daily JW, Park S.   +4 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Stable transgene expression and CRISPR-mediated knock-in system of a bacteria-derived antibiotic selection gene in the green alga Ulva prolifera. [PDF]

BMC Plant Biol
Qin Z, Surnido W, Mizuta H, Uji T.
europepmc   +1 more source

The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.

Blood, 2011
D. Rossi, V. Spina, C. Deambrogi, S. Rasi, L. Laurenti, K. Stamatopoulos, L. Arcaini, M. Lucioni, G. Rocque, Z. Xu-Monette, C. Visco, Julie E. Chang, E. Chigrinova, F. Forconi, R. Marasca, C. Besson, T. Papadaki, M. Paulli, L. Larocca, S. Pileri, V. Gattei, F. Bertoni, R. Foà, K. Young, G. Gaidano   +24 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Author Correction: Binary vector copy number engineering improves Agrobacterium-mediated transformation. [PDF]

Nat Biotechnol
Szarzanowicz MJ, Waldburger LM, Busche M, Geiselman GM, Kirkpatrick LD, Kehl AJ, Tahmin C, Kuo RC, McCauley J, Pannu H, Cui R, Liu S, Hillson NJ, Brunkard JO, Keasling JD, Gladden JM, Thompson MG, Shih PM.   +17 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Non-seed plant research in the spotlight. [PDF]

Biol Open
El Mahboubi K, Romani F.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Research progress and applications of reverse genetics systems for infectious bronchitis virus. [PDF]

Poult Sci
Zhao Y.
europepmc   +1 more source