Results 191 to 200 of about 462,471 (291)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Simplifying causal gene identification in GWAS loci. [PDF]

PLoS Genet
Schipper M, Ulirsch J, Posthuma D, Ripke S, Heilbron K.   +4 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fundamentals of big data and artificial intelligence in transfusion medicine. [PDF]

Vox Sang
Turki AT, Brieske CM, Gurkan UA, Scheidler KM, Usta OB, Turkulainen E, Arzideh K, Temme C, Hosch R, Horn PA, Arvas M.   +10 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Consensus recommendations from the 2024 International Follicular Lymphoma Scientific Workshop. [PDF]

Blood Adv
Merryman R, Rutherford SC, Ansell S, Armand P, Leonard JP, Nastoupil L, Smith SM, Timmerman J, Zelenetz AD, Gutierrez M, Béguelin W, Casulo C, Cerhan J, Green M, Kahl B, Kridel R, Link B, Maurer MJ, Nadel B, Radtke AJ, Luttwak E, Salles G, Sehn L, Pasqualucci L, LaCasce AS.   +24 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Giant Cell Tumor of Bone: Biology, Pathophysiology, and Histopathology in the Era of H3F3A. [PDF]

Biomedicines
Carneiro BD, Brilhante S, Faria CS, Fonseca S, Pozza DH.   +4 more
europepmc   +1 more source

Preliminary results of a protein electrophoretic analysis of genetic variation, population structure and gene flow in the Nassau grouper, Epinephelus striatus [PDF]

, 2005
Hateley, J.G.
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source