Results 191 to 200 of about 569,350 (369)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

, 2019
Caty Carrera, Natàlia Cullell, Nuria P. Torres‐Aguila, Elena Muiño, Alejandro Bustamante, Antonio Dávalos, Elena López‐Cancio, Marc Ribó, Carlos A. Molina, Eva Giralt‐Steinhauer, Carolina Soriano‐Tárraga, Marina Mola-Caminal, Jordi Jiménez‐Conde, Jaume Roquer, Cristòfol Vives-Bauzà, Rosa Díaz-Navarro, Vı́ctor Obach, Juan F. Arenillas, Tomás Segura, Gemma Serrano‐Heras, Joan Martí–Fàbregas, Marimar Freijó, Juan Antonio Cabezas, Turgut Tatlisumak, Laura Heitsch, Laura Ibáñez, Carlos Cruchaga, Jin‐Moo Lee, Daniel Strbian, Joan Montaner, Israel Fernández‐Cadenas   +30 more
openalex   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Efficient genetic transformation and gene editing of Chinese cabbage using Agrobacterium rhizogenes. [PDF]

Plant Physiol
Wang Y, Yang X, Wang W, Wang Y, Chen X, Wu H, Gao Z, Xu H, Liu T, Li Y, Xiao D, Liu W, Hou X, Zhang C.   +13 more
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Development of an improved construct for spectinomycin selection in plant transformation. [PDF]

BMC Res Notes
McCue KF, Shao M, Huynh J, Minh T, Chan M, Moy Y, Thomson JG.   +6 more
europepmc   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Correction to: ETV6::ABL1 fusion: from overlooked minor clone in myeloproliferative neoplasm to major player in leukemic transformation. [PDF]

Virchows Arch
Lee HW, Park MS, Kim B, Jung CW, Kim HJ, Kim HY.   +5 more
europepmc   +1 more source

Molecular validation of genetically transformed Catharanthus roseus plants via different strains of Agrobacterium tumefaciens

Heliyon
Medical plants play a crucial role in the pharmaceutical industry due to their natural synthesis of active compounds. Synthetic methods exist, which provide fewer effective molecules compared to those naturally occurring.
Rania El-Tanbouly, Hend Hassan, Lojina M. Awd, Azza Ali Makhlouf, Hani G. Shalabi, Sarah El-Messeiry   +5 more
doaj