Results 191 to 200 of about 439,059 (350)

Genome editing in the green alga Chlamydomonas: past, present practice and future prospects. [PDF]

Plant J
Nievergelt AP.
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Efficient Virus-Induced Gene Silencing (VIGS) Method for Discovery of Resistance Genes in Soybean. [PDF]

Plants (Basel)
Deng K, Lu Z, Yang H, Chen S, Li C, Cao D, Wang H, Hao Q, Chen H, Shan Z.   +9 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Development of an improved construct for spectinomycin selection in plant transformation. [PDF]

BMC Res Notes
McCue KF, Shao M, Huynh J, Minh T, Chan M, Moy Y, Thomson JG.   +6 more
europepmc   +1 more source

The Geneticists\u27 Approach to Bilski [PDF]

, 2011
Boughman, Joann A., Brown, Kyle M.
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Simply cut out - Combining CRISPR/Cas9 RNPs and transiently selected telomere vectors for marker free-gene deletion in <i>Trichoderma atroviride</i>. [PDF]

Front Genome Ed
Gründlinger M, Ellensohn C, Drechsel L, Schreiner U, Pierson S, Baldin C, Zeilinger S.   +6 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Genomic variant profiling in blast-phase paediatric chronic myeloid leukaemia: Predisposing and driving alterations. [PDF]

Br J Haematol
Behrens YL, Reinkens T, Hofmann W, Gumann A, Förster A, Gaschler L, Ghete T, Strasser R, Espenkötter J, Haermeyer B, Losch M, Sembill S, Wotschofsky Z, von Hörsten S, Schuh W, Di Donato N, Suttorp M, Krumbholz M, Ripperger T, Schlegelberger B, Göhring G, Metzler M, Karow A.   +22 more
europepmc   +1 more source