Results 51 to 60 of about 439,059 (350)

Genomic and Genetic Insights Into a Cosmopolitan Fungus, Paecilomyces variotii (Eurotiales)

Frontiers in Microbiology, 2018
Species in the genus Paecilomyces, a member of the fungal order Eurotiales, are ubiquitous in nature and impact a variety of human endeavors. Here, the biology of one common species, Paecilomyces variotii, was explored using genomics and functional ...
Andrew S. Urquhart, Stephen J. Mondo, Miia R. Mäkelä, James K. Hane, James K. Hane, Ad Wiebenga, Guifen He, Sirma Mihaltcheva, Jasmyn Pangilinan, Anna Lipzen, Kerrie Barry, Ronald P. de Vries, Igor V. Grigoriev, Alexander Idnurm   +13 more
doaj   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Preparation and evaluation of Brucella T4SS recombinant proteins in serodiagnosis of human brucellosis based on TMT-based proteomics technology

Frontiers in Cellular and Infection Microbiology
IntroductionBrucellosis, a significant zoonotic infectious disease, poses a global health threat. Accurate and efficient diagnosis is crucial for prevention, control, and treatment of brucellosis. VirB proteins, components of the Type IV secretion system
Qi Wu, Chen Sun, Liping Guo, Yujia Xie, Jinpeng Zhang, Jinpeng Zhang, Dehui Yin, Dehui Yin   +7 more
doaj   +1 more source

Improved injection needles facilitate germline transformation of the buckeye butterfly Junonia coenia

BioTechniques, 2014
Germline transformation with transposon vectors is an important tool for insect genetics, but progress in developing transformation protocols for butterflies has been limited by high post-injection ova mortality.
Kahlia Beaudette, Tia M. Hughes, Jeffrey M. Marcus   +2 more
doaj   +1 more source

On the Possible Transformation and Vanishment of Epistemic Objects [PDF]

, 2016
When considering the question of possible transformation and disappearance of scientific objects, it is useful to distinguish between epistemic and technical objects. This paper presents preliminary observations and offers a typology of obsolescence.
Rheinberger, Hans-Jörg
core  

Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict [PDF]

, 2016
Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial.
A Adams, A Adams, AB Dalia, AI Khan, B Martin, BJ Haijema, BR Levin, C Boutry, C Buchrieser, C Camacho, C Canchaya, C Chewapreecha, C Fraser, C Johnston, C Johnston, C Johnston, Christophe Fraser, Christopher Wymant, CS Wylie, D Dubnau, D Hyatt, DA Baltrus, DA Caugant, DA Higgins, DA Morrison, DA Morrison, DE Fouts, DJP Engelmoer, E Borezee, E Szathmáry, E V Pestova, E Zaccaria, EA Campbell, EJ Feil, EJ Gaasbeek, EJ Gaasbeek, EP Rocha, ES Antonova, F Ginetti, F Griffith, F Liu, GG Wilson, GJ Stewart, GM Süel, GW Goldberg, H Bagci, H Bernstein, H Deveau, H Li, H Maamar, H Muller, H Ochman, H Tong, H-H Chou, HC Neu, I Chen, I Mortier-Barriere, I Mortier-Barrière, J Bondy-Denomy, J Guglielmini, J Majewski, J Majewski, J-P Claverys, JA Lanie, JA Londoño-Vallejo, JA Mongold, JC Lefevre, JC Mell, JH Stuy, JJ Sakamoto, JK Setlow, JM Auchtung, JM Musser, JM Smith, JM Smith, JO McInerney, JP Claverys, JP Claverys, JT Simpson, JW Beaber, K Turgay, KS Makarova, KT Konstantinidis, L Attaiech, L Fontaine, L Van Valen, L-M Bobay, LP Macfadyen, LS Frost, LS Håvarstein, LS Håvarstein, M Berge, M Boetzer, M Del Grosso, M Prudhomme, M Ramirez, MA Hoelzer, ME Kahn, MF Wojciechowski, MJ Lopez-Sanchez, ML Gwinn, MR Oggioni, MS Dorer, MTG Holden, Nicholas J. Croucher, Nick H. Barton, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, O Johnsborg, OE Cornejo, OH Ambur, OT Avery, P Glaser, P Jorth, P Luo, PA Levin, Paul Turner, PJ Johnsen, R Davidoff-Abelson, R Edgar, R Mostowy, RA Fisher, Rafal Mostowy, RE Michod, RE Yasbin, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RK Aziz, RP Novick, S Lacks, SA McMahon, SB Beres, SE Finkel, SJ Labrie, SP Otto, Stephen D. Bentley, T Carver, T Nozawa, U Munoz-Najar, WA Sweetman, WJ Kent, X Charpentier, X Charpentier, X Didelot, Y Li, Z Zhou   +157 more
core   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Preparation and application of specific chicken yolk antibodies in detecting Brucella

Frontiers in Veterinary Science
Brucellosis, caused by Brucella, is a severe zoonotic disease. Conventional IgG antibody-based ELISA testing faces challenges such as false positives and cross-reactivity.
Xinru Qi, Shiqi Zhao, Qianhan Huang, Yun Wang, Qichuan Pei, Yixiao Chen, Dehui Yin, Dehui Yin, Tiansong Zhan, Tiansong Zhan   +9 more
doaj   +1 more source

Exact Solution of the Multi-Allelic Diffusion Model

, 2005
We give an exact solution to the Kolmogorov equation describing genetic drift for an arbitrary number of alleles at a given locus. This is achieved by finding a change of variable which makes the equation separable, and therefore reduces the problem with
Baxter, G., Blythe, R. A., McKane, A. J.
core   +2 more sources