Results 51 to 60 of about 2,830,856 (315)

Role of Epigenetics in the Pathogenesis, Treatment, Prediction, and Cellular Transformation of Asthma

Mediators of Inflammation, 2021
Asthma is a mysterious disease with heterogeneity in etiology, pathogenesis, and clinical phenotypes. Although ongoing studies have provided a better understanding of asthma, its natural history, progression, pathogenesis, diversified phenotypes, and ...
Binaya Wasti, Shaokun Liu, X. Xiang
semanticscholar   +1 more source

Multiple testing correction in linear mixed models. [PDF]

, 2016
BackgroundMultiple hypothesis testing is a major issue in genome-wide association studies (GWAS), which often analyze millions of markers. The permutation test is considered to be the gold standard in multiple testing correction as it accurately takes ...
Eskin, Eleazar, Han, Buhm, Hormozdiari, Farhad, Joo, Jong Wha J   +3 more
core   +2 more sources

Highly efficient transformation of the model zygnematophycean alga Closterium peracerosum-strigosum-littorale complex by square-pulse electroporation.

New Phytologist, 2021
The zygnematophycean algae occupy an important phylogenetic position as the closest living relatives of land plants. Reverse genetics is quite useful for dissecting the functions of genes. However, this strategy requires genetic transformation, and there
J. Kawai, Manaki Kanazawa, Rie Suzuki, Nanako Kikuchi, Y. Hayakawa, H. Sekimoto   +5 more
semanticscholar   +1 more source

Advances in Genetics and Molecular Breeding of Broccoli

Horticulturae, 2021
Broccoli (Brassica oleracea L. var. italica) is one of the most important vegetable crops cultivated worldwide. The market demand for broccoli is still increasing due to its richness in vitamins, anthocyanins, mineral substances, fiber, secondary ...
F. Han, Yumei Liu, Zhiyuan Fang, Limei Yang, M. Zhuang, Yang-yong Zhang, H. Lv, Yong Wang, J. Ji, Zhansheng Li   +9 more
semanticscholar   +1 more source

Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality. [PDF]

, 2020
Metabolic adaptation is linked to the ability of the opportunistic pathogen Candida albicans to colonize and cause infection in diverse host tissues. One way that C.
Filler, Scott G, Huang, Manning Y, Lagree, Katherine, May, Gemma, McManus, C Joel, Mitchell, Aaron P, Solis, Norma V, Woolford, Carol A   +7 more
core   +3 more sources

One-Step Assembly of a Porcine Epidemic Diarrhea Virus Infectious cDNA Clone by Homologous Recombination in Yeast: Rapid Manipulation of Viral Genome With CRISPR/Cas9 Gene-Editing Technology

Frontiers in Microbiology, 2022
Porcine epidemic diarrhea virus (PEDV), a swine enteric coronavirus causing acute diarrhea in piglets, is one of the major threatens to the pork industry globally.
Yanyang Zhou, Chenxi Li, Chenxi Li, Chenxi Li, Cicheng Ren, Jingbo Hu, Changxu Song, Xinjie Wang, Yanhua Li, Yanhua Li, Yanhua Li   +10 more
doaj   +1 more source

A versatile Agrobacterium-based plant transformation system for genetic engineering of diverse citrus cultivars

Frontiers in Plant Science, 2022
Developing an efficient transformation system is vital in genetically engineering recalcitrant crops, particularly trees. Here, we outline an Agrobacterium tumefaciens-based stable plant transformation methodology for citrus genetic engineering.
Michelle M. Dominguez, Carmen S. Padilla, Kranthi K. Mandadi, Kranthi K. Mandadi, Kranthi K. Mandadi   +4 more
doaj   +1 more source

An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci [PDF]

, 2010
A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event
A. Eyre-Walker, A. Fox, A. S. Kondrashov, A. S. Kondrashov, A. S. Kondrashov, B. Balkau, B. Charlesworth, B. Charlesworth, B. Charlesworth, C. F. Baer, C. Hoede, E. Deutsch, F. A. Kondrashov, F. Ababneh, F. Rodríguez, F. Squartini, I. M. Singer, J. F. C. Kingman, J. F. C. Kingman, J. H. Wilkinson, J. J. Duistermaat, J. Keilson, J. R. Munkres, K. E. Holsinger, K. E. Holsinger, K. Holsinger, K. V. Pylkov, L. A. Zhivotovsky, L. A. Zhivotovsky, L. Altenberg, L. Altenberg, Lee Altenberg, M. Iosifescu, M. Lynch, M. Lynch, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Hirsch, R. A. Horn, R. C. Lewontin, R. N. Brandon, R. Teague, S. Karlin, S. Karlin, S. Karlin, S. Karlin, S. Karlin, S. P. Otto, S. Whelan, U. Liberman, U. Liberman, V. Guillemin, V. Jayaswal, W. C. Salmon, W. C. Salmon, W. Feller, Z. Yang, Z. Yang   +60 more
core   +2 more sources

Pleurotus ostreatus as a model mushroom in genetics, cell biology, and material sciences

Applied Microbiology and Biotechnology
Pleurotus ostreatus , also known as the oyster mushroom, is a popular edible mushroom cultivated worldwide. This review aims to survey recent progress in the molecular genetics of this fungus and demonstrate its potential as a model mushroom for future ...
T. Nakazawa, Moriyuki Kawauchi, Yuitsu Otsuka, Jun-Woo Han, D. Koshi, Kim Schiphof, Lucía Ramírez, A. Pisabarro, Yoichi Honda   +8 more
semanticscholar   +1 more source

The maintenance of sex in bacteria is ensured by its potential to reload genes

, 2006
Why sex is maintained in nature is a fundamental question in biology. Natural genetic transformation (NGT) is a sexual process by which bacteria actively take up exogenous DNA and use it to replace homologous chromosomal sequences.
Derenyi, Imre, Szollosi, Gergely J., Vellai, Tibor   +2 more
core   +2 more sources