Results 91 to 100 of about 3,280,020 (335)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

F-Expansive transformation groups

General Topology and its Applications, 1979
AbstractAn initial investigation in F-expansion relative to families of continuous functions on the acting group is presented, modelled after previous work of Bowen and Walters on real flows. Basic properties are established, and expansion in the natural class of non-trivial homomorphisms is extensively studied.
Keynes, H.B., Sears, M.
openaire   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The New ‘Golden Age’ of Dentistry: A Highly Desirable Profession with Unprecedented Global Opportunities in Industry Settings

Journal of the California Dental Association
Background Dentistry 1.0, an era where the patient journey was embedded in fully analog realities gave way to a 2.0 era of select digitalization since the late 1990s. Now, we are arguably at another tipping point, where for the foreseeable future digital
Artemiz Seif, Christian R. Jarry, Amélie Michèle Chauvel   +2 more
doaj   +1 more source

Understanding the Implementation of Airbnb in Urban Contexts: Towards a Categorization of European Cities

Land, 2020
The sharing economy has experienced exponential growth in recent years, especially in the short-term rentals (STRs) tourist accommodation sector. This growth has caused disruptive effects in rural and urban contexts, especially in highly touristic cities.
Laura Serrano, Antonio Sianes, Antonio Ariza-Montes   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Artificial intelligence for biodiversity and tourism governance: predictive insights from multilayer perceptron models in Amazonia

Frontiers in Artificial Intelligence
Tourism in biodiversity-rich regions was among the sectors most severely disrupted by the COVID-19 pandemic, which amplified existing socioeconomic vulnerabilities and placed cultural and natural heritage conservation at risk.
Jessie Bravo-Jaico, Oscar Serquén, Roger Alarcón, Juan Eduardo Suarez-Rivadeneira, Wilfredo Ruiz-Camacho, Freddy A. Manayay   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Oculopalpebral prosthesis prototype design using the additive manufacturing technique: A case study

JPRAS Open
Three-dimensional (3D) printing technology has advanced for applications in the field of reconstructive surgery. This study reports the application of a comprehensive methodology to obtain an anatomical model, using computed tomography and 3D printing ...
E. Vázquez-Silva, D.D. Bohorquez-Vivas, P.G. Peña-Tapia, F.P. Moncayo-Matute, P.B. Torres-Jara, D.P. Moya-Loaiza   +5 more
doaj   +1 more source