Results 71 to 80 of about 3,280,020 (335)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Piecewise Linear Groups and Transformation Groups [PDF]

Transactions of the American Mathematical Society, 1969
The object of this paper is to show, via specific theorems, that the notions of topological group and transformation group become severely restricted when transposed to the piecewise linear category. Let us understand a piecewise linear (PL) group to be a topological group G together with a piecewise linear structure on G (i.e., triangulation of G as a
openaire   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tislelizumab Plus Zanubrutinib in Patients with Richter Transformation: Primary Endpoint Analysis of the Prospective, Multi-Center, Phase-II RT1 Trial of the German CLL Study Group [PDF]

, 2023
Othman Al‐Sawaf, Rudy Ligtvoet, Sandra Robrecht, Janina Stumpf, Anna Maria Fink, Eugen Tausch, Christof Schneider, Sebastian Böttcher, Martin Mikusko, Matthias Ritgen, Johannes Schetelig, Julia von Tresckow, Ursula Vehling‐Kaiser, Clemens‐Martin Wendtner, Kirsten Fischer, Karl Anton Kreuzer, Stephan Stilgenbauer, Philipp B. Staber, Carsten Utoft Niemann, Michael Hallek, Barbara Eichhorst   +20 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Unlocking Learning: Investigating the Replayability of Educational Games

International Journal of Computer Games Technology
Recently, gamification has emerged as an effective approach to captivate users, particularly in the context of online education. Although there has been a rise in the recent surge of articles on gamification, there is still a lack of research on the ...
Rose Oluwaseun Adetunji, Abejide Ade-Ibijola   +1 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Implementing continuous glucose monitoring in public primary care for type 2 diabetes management: a convergent mixed-methods study of patient and provider experiences in Singapore

BMC Primary Care
Background Type 2 diabetes (T2D) is highly prevalent in Singapore, yet glycemic control remains suboptimal in primary care. Continuous glucose monitoring (CGM) offers real-time feedback that may improve self-management, but adoption in Asian primary care
Shilpa Tyagi, Keith Sng, David Wei Liang Ng, Valerie Hui Ying Teo, Si Min Thio, Jeremy Cong En He, Chun Yen Beh, Ming Hann Cheah, Nooradlin Marina Binti Mohammad Junaidi See Toh, Jiawei Chen, Gerald Choon-Huat Koh   +10 more
doaj   +1 more source

On lifting transformation groups [PDF]

Proceedings of the American Mathematical Society, 1968
It is known [1] that if (X, G, IA) is a topological transformation group such that 7r1(G) = 0, and if X is a covering space of X, then there is a unique topological transformation group (5, G, ,) which covers (X, G, IA). In [2] the fundamental group o(X, xo, G) of a group of homeomorphisms G of a topological space X is defined,, and, it is observed in ...
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source