Results 81 to 90 of about 1,672,113 (290)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Algebraic construction of the Darboux matrix revisited

, 2009
We present algebraic construction of Darboux matrices for 1+1-dimensional integrable systems of nonlinear partial differential equations with a special stress on the nonisospectral case.
Arnold W I, Bart H, Belinsky V A, Bobenko A I, Bobenko A I, Bohner M, Boiti M, Boutet de Monvel A, Burtsev S P, Cieśliński J, Cieśliński J L, Cieśliński J L, Cieśliński J L, Cieśliński J L, Coley A, Darboux G, Doktorov E V, Gohberg I, Gu G C, Gu G C, Guest M A, Hoenselaers C, Its A R, Jan L Cieśliński, Krichever I M, Leble S B, Levi D, Matveev V B, Mañas M, Meinel R, Mikhailov A V, Mikhailov A V, Neugebauer G, Nijhoff F, Nimmo J J C, Novikov S P, Oevel W, Pressley A N, Rogers C, Sakhnovich A L, Sakhnovich L A, Sakhnovich L A, Saleem U, Shabat A B, Shin H J, Terng C L, Uhlenbeck K, Zakharov V E, Zakharov V E, Zakharov V E, Zhou Z X   +50 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Analysis of the algorythms accuracy of the plane and space geodetic coordinates transformation

Geodesy and Cartography, 2012
The accuracy of the coordinates computed by transformation from one system to another is analysed. Values of transformation parameters are computed by the least-square method taking into account the accuracy of the coordinates of the identical points in ...
Jonas Skeivalas, Robertas Dargis
doaj   +1 more source

Helicity Entanglement of Moving Bodies

, 2009
We investigate the Lorentz transformation of the reduced helicity density matrix for a pair of massive spin 1/2 particles. The corresponding Wootters concurrence shows no invariant meaning, which implies that we can generate helicity entanglement simply ...
HONGBAO ZHANG, Pachos J., SHUXIN SHAO, SONG HE, Weinberg S.   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Realization in Generalized State Space form for 2-D Polynomial System Matrices

Sultan Qaboos University Journal for Science, 2005
In this paper, a direct realization procedure is presented that brings a general 2-D polynomial system matrix to generalized state space (GSS) form, such that all the relevant properties including the zero structure of the system matrix are retained.
M.S. Boudellioua, B. Chentouf
doaj   +1 more source

Computing Biquadratic Transformation Matrix [PDF]

Journal of Institute of Control, Robotics and Systems, 2009
Recently it has been shown in the literature that a biquadratic transformation can be used to deal with the pathological cases arising in the bilinear transformation. This paper concerns the computational aspect of the biquadratic transformation. Two efficient algorithms are presented to compute the transformation matrix.
openaire   +1 more source