Results 51 to 60 of about 704,600 (271)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Transformation optics in orthogonal coordinates

open access: yes, 2008
The author proposes the methodology of transformation optics in orthogonal coordinates to obtain the material parameters of the transformation media from the mapping in orthogonal coordinates. Several examples are given to show the applications of such a
Chen, Huanyang
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

On-Board Ortho-Rectification for Images Based on an FPGA

open access: yesRemote Sensing, 2017
The traditional ortho-rectification technique for remotely sensed (RS) images, which is performed on the basis of a ground image processing platform, has been unable to meet timeliness or near timeliness requirements.
Guoqing Zhou Rongting Zhang Na Liu Jingjin Huang and Xiang Zhou   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Measuring robot kinematics description and its workspace

open access: yesMATEC Web of Conferences, 2016
Text deals with 6 degree of freedom measuring robot kinematics description enabling manipulation with measuring effector in 3D space. Mentioned description flowing from Denavit- Hartenberg notation for serial ordering of ideally stiff bodies connected by
Úředníček Zdeněk, Drga Rudolf
doaj   +1 more source

An Analysis of the Accuracy of the Transformation of the Coordinators of Mining Maps by Distinct Method

open access: yesGeoinformatica Polonica, 2023
The article presents the results of an analysis of the accuracy of the transformation of the coordinates of the boundary points of neighbouring mining areas in Silesia.
Monika Żogała
doaj   +1 more source

Transformations of coordinates and Hamiltonian formalism in deformed Special Relativity

open access: yes, 2003
We investigate the transformation laws of coordinates in generalizations of special relativity with two observer-independent scales. The request of covariance leads to simple formulas if one assumes noncanonical Poisson brackets, corresponding to ...
G. Amelino-Camelia   +16 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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