Results 81 to 90 of about 704,600 (271)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
On ill-conditioning in 3D Similarity Transformation
International Journal of Environment and Geoinformatics, 2015 3D similarity transformations are often used for datum transformation in Geomatic Engineering. The transformations are routinely performed between the point coordinates evaluated from GNSS (Global Navigation Satellite Systems) observations and the ...
Orhan Kurt
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Polish Cartographical ReviewInitial cartographic materials were determined to create the topographic database of the “Main State Topographic Map”. They require preparation for creating (updating) digital topographic maps at the scale of 1:50,000. One of the stages of preparation of
Karpinskyi Yurii +3 more
doaj +1 more source
On the transformation of the coordinates of points from the SK-42 system to WGS-84
Геофизический журнал, 2019 The significant and effective use of global positioning satellite systems for solution of important theoretical and applied problems of Earth sciences means the preserving of the possibility to use a huge quantity of geodetic, cartographic, gravimetric ...
A. I. Yakimchik
doaj +1 more source
The transformation of external harmonic series under a translation of origin [PDF]
Transformation properties of coordinates in inverse power spherical harmonic ...
Madden, S. J., Jr.
core +1 more source