Results 41 to 50 of about 492,859 (311)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Religion and politics of belonging in digital times: youth religiosity in focus

Frontiers in Political Science
Political responses to growing diversity are often characterised by one-dimensional attempts to pin down a collective identity. In stark contrast, we see that young people in diverse urban areas negotiate their multiple, flexible belonging both on- and ...
Astrid Mattes, Miriam Haselbacher, Katharina Limacher, Christoph Novak   +3 more
doaj   +1 more source

A broadband polygonal cloak for acoustic wave designed with linear coordinate transformation [PDF]

, 2016
Previous acoustic cloaks designed with transformation acoustics always involve inhomogeneous material. In this paper, a design of acoustic polygonal cloak is proposed using linear polygonal transformation method. The designed acoustic polygonal cloak has
Zheng, Bin, Rongrong Zhu, Chen, Hongsheng, Chu Ma, Ma, Chu, Fang, Nicholas, Fang, Xuanlai, Jun Xu, Xu, Jun, Bin Zheng, Hongsheng Chen, Nicholas Fang, Zhu, Rongrong   +12 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A research agenda for the science of actionable knowledge: Drawing from a review of the most misguided to the most enlightened claims in the science-policy interface literature [PDF]

, 2023
Linking science with action affords a prime opportunity to leverage greater societal impact from research and increase the use of evidence in decision-making. Success in these areas depends critically upon processes of producing and mobilizing knowledge,
Jagannathan, Kripa, Turnhout, Esther, Gabrielle Wong-Parodi, Angela T. Bednarek, Nichols, Leah, Meyer, Ryan, Wong-Parodi, Gabrielle, Oldach, Eliza, Alison Meadow, K. Dana Sjostrom, Katharine J. Mach, Nicole Klenk, Leah Nichols, Sjostrom, K. Dana, Neff, Mark, Moss, Richard H., Richard H. Moss, Bednarek, Angela T, Maria Carmen Lemos, Bednarek, Angela T., Klenk, Nicole, Esther Turnhout, Christine J. Kirchhoff, Aparna Bamzai-Dodson, Turnhout, Esther; id_orcid, Kirchhoff, Christine J., Ryan Meyer, Kristin M.F. Timm, Mark Neff, Sjostrom, K.D., Art Dewulf, Moss, Richard H, Carmen Lemos, Maria, Timm, Kristin M.F., Kristen Goodrich, Bamzai-Dodson, Aparna, James Arnott, Eliza Oldach, Kripa Jagannathan, Mach, Katharine J., Geniffer Emmanuel, Emmanuel, Geniffer, Lemos, Maria Carmen, Sjostrom, K Dana, Arnott, James, Dewulf, Art, Kirchhoff, Christine J, Meadow, Alison, Mach, Katharine J, Timm, Kristin MF, Goodrich, Kristen   +50 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Cultural Education for Sustaining Nusantara Religion Within Boti Indigenous Community

Al-Albab, 2023
Boti indigenous community which is in Timor Tengah Selatan district, Nusa Tenggara Timur preserves and nurtures their Nusantara religion, named Uis Neno ma Uis Pah. Boti is able to live through different eras, before West influences, the colonization era,
Octalyna Puspa Wardany, Al Makin, Samsul Maarif   +2 more
doaj   +1 more source

Civil Society in Conflict Transformation: Strengths and Limitations [PDF]

, 2011
This book chapter focuses on the potential contribution that civil society actors can make to peacebuilding. There is also an examination of what types of activities international and transnational NGOs undertake in order to influence international ...
Fischer, Martina
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source