Results 71 to 80 of about 492,859 (311)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Wittgenstein and the Old Testament

open access: yesReligions
I start this paper by giving a general account of Wittgenstein’s relationship to the Bible, especially to the Old Testament. I will then examine those passages in his work where he explicitly refers to the Old Testament.
Esther Heinrich
doaj   +1 more source

The European Union, Conflict Transformation and Civil Society: A Conceptual Framework [PDF]

open access: yes
The European Union considers conflict resolution as a cardinal objective of its foreign policy. It makes use of a number of policy instruments to promote conflict transformation through ‘constructive engagement’, which cover a range of sectors affecting ...
Nathalie Tocci
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Civil Society and Conflict Transformation in Abkhazia, Israel/Palestine, Nagorno-Karabakh, Transnistria and Western Sahara [PDF]

open access: yes
The paper describes and analyses the role of civil society in five conflict cases – Abkhazia, Nagorno-Karabakh, Transnistria, Western Sahara and Israel/ Palestine. It evaluates the relative effectiveness of civil society organisations (CSOs) and assesses
Nona Mikhelidze, Nicoletta Pirozzi
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

TRANSFORMATION OF FAMILY IN MODERN RUSSIAN SOCIETY

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2014
The article examines concept of family in Russian society, changes in interpretation of family, connected with modern tendencies and processes in different sociocultural spheres.
Olga Anatolevna Otradnova
doaj   +1 more source

Transformation of communication practices : a case study of older adults' participation in the information society [PDF]

open access: yes, 2002
The info1mation society marks a shift from the dominance of the industrial to the rise of the "informational" (Castells, 1996, p. 21 ). The effects of this shift on social arrangements generally have been greeted in diverse ways, ranging from the ...
Barnett, Karen Rae
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Cinema of the Desert: The Fight of the Ascetic Women

open access: yesReligions
This paper examines the cinematic portrayals of ascetic women within contemporary film. Historically, the early desert fathers and mothers are venerated figures who embody a life of ascesis—spiritual discipline amidst the deserts of Egypt, Palestine, and
Milja Radovic
doaj   +1 more source

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