Results 111 to 120 of about 4,810,010 (300)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Guide to The Notification System for Exempt Medicinal Products

open access: yes, 2020
This document gives guidance in the area of exempt (unauthorised) medicinal products and their sourcing and supply to the Irish market. It describes the system for notification to the Health Products Regulatory Authority (HPRA) of the receipt or ...
Health Products Regulatory Authority (HPRA)
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HPRA medicinal products newsletter: issue 68

open access: yes, 2021
• Approval Dates for Package Leaflets • Nitrosamine Impurities • Article 31 Referral for Sartan Medicines – Reminder • Preparation of Labelling for Joint IE/UK (NI) Packs • Audits of Type IA Notifications: 2019/2020 Review • Reference Medicinal ...
Health Products Regulatory Authority (HPRA)
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Catalogue des Technologies de Transformation de Manioc

open access: yes
The purpose of this technology catalogue is to advance high quality cassava flour (HQCF) as a substitute for wheat in Africa. While Africa has the potential to increase its wheat production, it appears to be small in proportion to the massive demand for ...
Technologies for African Agricultural Transformation
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Ozone induced structural variation in OSA waxy rice starch: Effects on the thermal behavior of starch and its stabilized pickering emulsion

open access: yesFood Chemistry: X
Waxy rice starch (St) was modified by pre-OSA esterification reaction followed by ozone treatment. The molecular structure of this modified product (OSA-OSt) was characterized, and the thermal behaviors and its stabilized Pickering emulsion were ...
Meng Du   +8 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Guide to Reporting and Initial Investigation of Quality Defects in Medicinal Products for Human and Veterinary Use

open access: yes, 2021
This is an industry guide for the following stakeholder groups: - marketing authorisation holders (MAHs) - registration holders - clinical trial sponsors - manufacturers - wholesalers This guide covers the reporting to the Health Products ...
Health Products Regulatory Authority (HPRA)
core  

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