Results 101 to 110 of about 4,810,010 (300)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Maximal subgroups of free idempotent-generated semigroups over the full transformation monoid [PDF]
, 2011 Let Tn be the full transformation semigroup of all mappings from the set {1, . . . , n} to itself under composition. Let E = E(Tn) denote the set of idempotents of Tn and let e ∈ E be an arbitrary idempotent satisfying |im (e)| = r ≤ n − 2. We prove that
Ruskuc, N. +3 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Digital transformation know how. Connecting digital transformation, agility and leadership
, 2020 In recent years, digital development has accelerated and digital turbulence is the new normal. So, it’s time for a synthesis, time to bring stability to that turbulence: What have we learned? What do we know?
Viaene, Stijn
core
, 2016 The transformation of captopril (CAP), a widely-used thiol drug, was studied with the presence of dissolved model humic constituents (HCs) in a laccase-catalyzed system. Reaction products were analyzed by ultra-performance liquid chromatography coupled
Zhao, He +4 more
core +1 more source
Transformation enhancing factors and fibronectin degradation products as possible tumor markers.
, 1983 Transformation enhancing factors and fibronectin degradation products as possible tumor ...
Vartio T. +3 more
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Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Guide to Wholesaling and Brokering of Medicinal Products for Human Use in Ireland
, 2022 The purpose of this document is to provide guidance on the regulations covering the wholesale distribution and brokering of medicinal products for human use in Ireland.
Health Products Regulatory Authority (HPRA)
core
Biodegradation of Emerging Contaminants Controlled by Biological and Chemical Factors
MicroorganismsEmerging contaminants (ECs) are organic compounds, including pharmaceuticals, personal care products, pesticides, and other chemicals, that are linked to harmful effects on aquatic environments.
Avela Mqambalala +3 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source