Results 81 to 90 of about 462,568 (264)

Iron-Modified Biochar/TiO₂ Advanced Oxidation Process for Enhanced Degradation of Norfloxacin and Estradiol in Water: Efficiency Optimization and Ecotoxicity Evolution of Transformation Products [PDF]

Iranian Journal of Chemistry & Chemical Engineering
This study aims to construct an advanced oxidation system using photocatalytically modified biochar to remove pharmaceutical residues (norfloxacin and estradiol) from water and evaluate the ecotoxicity of their degradation products.
Guirong Cao, Yue Li
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Binomial transform of products

, 2017
Given two infinite sequences with known binomial transforms, we compute the binomial transform of the product sequence. Various identities are obtained and numerous examples are given involving sequences of special numbers: Harmonic numbers, Bernoulli numbers, Fibonacci numbers, and also Laguerre polynomials.
openaire   +2 more sources

Pharmaceutical and Trace Metal Interaction within the Water–Soil–Plant Continuum: Implications for Human and Soil Health

Toxics
Unplanned water reuse for crop irrigation may pose a global health risk due to the entry of contaminants into the food chain, undesirable effects on crop quality, and impact on soil health.
Lesly Ayala Cabana, Ana de Santiago-Martín, Raffaella Meffe, Isabel López-Heras, Irene de Bustamante   +4 more
doaj   +1 more source

Product Transform [PDF]

, 2021
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genomic, Transcriptomic and Suspect/Non‐Target Screening Analyses Reveal the Role of CYP450s in the Degradation of Imazalil and Delineate Its Transformation Pathway by Cladosporium herbarum

Microbial Biotechnology
Imazalil (IMZ), a major surface water contaminant characterised by high environmental recalcitrance and toxicity, is used in fruit‐packaging plants to control fungal infestations during storage. This leads to the production of wastewaters which should be
Christina V. Papazlatani, Sotirios Vasileiadis, Eleni I. Panagopoulou, Dimitrios E. Damalas, Panagiotis A. Karas, Evdoxia Gerovasileiou, Nikolaos S. Thomaidis, Dimitrios G. Karpouzas   +7 more
doaj   +1 more source

Efficacy of novel bacterial consortia in degrading fipronil and thiobencarb in paddy soil: a survey for community structure and metabolic pathways

Frontiers in Microbiology
IntroductionFipronil (FIP) and thiobencarb (THIO) represent widely utilized pesticides in paddy fields, presenting environmental challenges that necessitate effective remediation approaches.
Nastaran Faridy, Ehssan Torabi, Ahmad Ali Pourbabaee, Ebrahim Osdaghi, Khalil Talebi   +4 more
doaj   +1 more source