Results 41 to 50 of about 85,416 (307)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Natural Language Processing for Sentiment Analysis in Socialmedia Techniques and Case Studies [PDF]
ITM Web of ConferencesSocial media platforms have become a significant medium for expressing opinions, emotions, and sentiments, making sentiment analysis a crucial task in Natural Language Processing (NLP).
Veluswamy Anusha Sowbarnika +5 more
doaj +1 more source
, 2023 The recent developments of deep learning cover a wide variety of tasks such as image classification, text translation, playing go, and folding proteins. All these successful methods depend on a gradient-based learning algorithm to train a model on massive amounts of data using significant computation power.
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Contextual Emotion Recognition Using Transformer-Based Models
, 2023 In order to increase the precision of emotion identification in text, this research suggests a context-aware emotion recognition system employing transformer models, especially BERT.
Aayush Devgan (16709067)
core +1 more source
Applied SciencesEmotion recognition using AI has garnered significant attention in recent years, particularly in areas such as fashion, where understanding consumer sentiment can drive more personalized and effective marketing strategies.
Gaeun Lee, Seoyun Yi, Jongtae Lee
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Conditional Transformation Models [PDF]
Journal of the Royal Statistical Society Series B: Statistical Methodology, 2013 SummaryThe ultimate goal of regression analysis is to obtain information about the conditional distribution of a response given a set of explanatory variables. This goal is, however, seldom achieved because most established regression models estimate only the conditional mean as a function of the explanatory variables and assume that higher moments are
Hothorn, Torsten +2 more
openaire +5 more sources