Results 51 to 60 of about 85,416 (307)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ArabBert-LSTM: improving Arabic sentiment analysis based on transformer model and Long Short-Term Memory

Frontiers in Artificial Intelligence
Sentiment analysis also referred to as opinion mining, plays a significant role in automating the identification of negative, positive, or neutral sentiments expressed in textual data.
Wael Alosaimi, Hager Saleh, Hager Saleh, Hager Saleh, Ali A. Hamzah, Nora El-Rashidy, Abdullah Alharb, Ahmed Elaraby, Sherif Mostafa   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Toward Early Detection of Depression: Detecting Depression Symptoms in Arabic Tweets Using Pretrained Transformers

IEEE Access
The COVID-19 pandemic and its associated setbacks have significantly impacted human mental health. Depression of various intensities has resulted due to a wide variety of losses that people have experienced.
Suzan Elmajali, Irfan Ahmad
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Transformer-based Models for Enhanced Amur Tiger Re-Identification

Rapid urban growth, with its profound impact on natural habitats, intensifies the global risk faced by many wildlife species, driving them closer to the brink of extinction due to factors like habitat destruction, illegal hunting, and the challenges ...
Bai, Xufeng, Islam, Tasmina, Bin Azhar, M A Hannan   +2 more
core   +1 more source

Smart Defect Detection in Aero-Engines: Evaluating Transfer Learning with VGG19 and Data-Efficient Image Transformer Models

Machines
This study explores the impact of transfer learning on enhancing deep learning models for detecting defects in aero-engine components. We focused on metrics such as accuracy, precision, recall, and loss to compare the performance of models VGG19 and DeiT
Samira Mohammadi, Vahid Rahmanian, Sasan Sattarpanah Karganroudi, Mehdi Adda   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Automated Lithology Segmentation of 3D Point Clouds from Highwalls Using Deep Learning

Remote Sensing
Digital twins are increasingly being adopted to support efficient hazard assessment and predictive modelling. A key prerequisite for the development of reliable digital twins in rock slope engineering is the accurate identification and segmentation of ...
Umair Iqbal, Anna Giacomini, Klaus Thoeni   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source