Results 221 to 230 of about 1,377,829 (293)

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

A Smart Fluid‐Hydraulic System Based on MRF Valve Control and Its Application in Flexible Grasping

Advanced Science, EarlyView.
This study introduces a smart fluid hydraulic system using MRF valve control for flexible gripping. An MRF‐MSV with an integrated excitation coil and micro‐textured damping channels is designed and validated; micro‐texturing increases hydraulic resistance. Coupled with a soft actuator, the MRF‐MSV enables dynamic bending and grasping.
Linfeng Huo, Hui Ji, Ruidong Hong, Songlin Nie, Fanglong Yin, Zhonghai Ma   +5 more
wiley   +1 more source

Kresling Origami‐Based Metamaterial Robot for Dynamic Electromagnetic Control

Advanced Science, EarlyView.
A reconfigurable metamaterial system integrates deformable origami units with high‐permittivity ceramic plates. Pneumatic switching between structural states alters local resonance conditions, enabling dynamic radar stealth and adaptive microwave reflection for mobile communication.
Xinxi Zeng, Long Zhou, Shaojie Xi, Yixuan Gao, Desheng Pan, Chaoyang Sun, Haoxin Sun, Xian Wang, Lingyun Qian, Peipei Li, Pengfei Zhu, Bo Li, Jiang Luo, Ji Zhou   +13 more
wiley   +1 more source

Interface‐Directed High Fluorescence Efficiency Two‐Dimensional Molecular Crystals With Surface‐Exposed Active Sites

Advanced Science, EarlyView.
Here, we designed the Me‐FBSe molecule and prepared a two‐dimensional molecular crystal via liquid‐liquid interface assembly. The crystal preserves the high photoluminescence quantum while simultaneously ensuring the high‐density surface exposure of active sites.
Shuya Liu, Yueqiang Zhang, Chuanqin Cheng, Jin Wang, Feiyong Chen, Yonglei Wang, Yanjun Gong   +6 more
wiley   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Efficient Adsorption‐Based Direct Air Capture Via Triply Periodic Minimal Surface Architectures

Advanced Science, EarlyView.
Architected triply periodic minimal surface (TPMS) contactors reshape direct air capture by replacing straight‐channel diffusion limits with convection‐enhanced CO2 transport. Chaotic advection thins boundary layers and exposes fast adsorption sites, enabling 70%–75% more fast sites, 114% higher productivity, and 51.8% lower energy consumption than ...
Qingyang Shao, Zhuozhen Gan, Chengcheng Long, Man Zhang, Yihe Miao, Yuehui Li, Xuancan Zhu   +6 more
wiley   +1 more source

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation

Advanced Science, EarlyView.
Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai, Shuhong Wang, Chenguang Ding, Xenia Kostoulias, Anton P. Le Brun, Hsien‐Yi Hsu, Jhih‐Hang Jiang, Yajun Wang, Richard A. Strugnell, Anton Y. Peleg, Hsin‐Hui Shen   +10 more
wiley   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source