Results 91 to 100 of about 201,186 (292)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Research on the Electrical Resonance Characteristics of Power Transformer Windings
When a power transformer subjected to transient over-voltages containing different harmonic components, the frequency components of over-voltages are coupled with the inherent electrical frequency of the transformer winding, which can induce high ...
Yanan Chang +4 more
core +1 more source
Известия Томского политехнического университета: Инжиниринг георесурсов, 2019 The relevance of the work. When producing, transporting and processing geo assets it is necessary to use various electrical equipment, the transformers are the main electricity distributors in this case.
Yusup Niyazbekovich Isaev +2 more
doaj +2 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Frequency Response Modelling of Transformer Windings Connected in Parallel
, 2020 This paper describes the approach to the frequency response modelling of transformer windings consisting of coils connected in parallel. At present, computer models are intensively developed with the aim of simulating the influence of faults on the ...
Szymon Banaszak +2 more
core +1 more source
Simulation of checking of mechanical state of the transformer windings by nanosecond impulse.
MATEC Web of Conferences, 2014 The detailed electrical model of the transformer windings was developed. The possibility of detecting negligible changes in the geometrical pattern of the windings was investigated by testing of the impulses with nanosecond rising edge.
Semenov A.S. +3 more
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source