Results 191 to 200 of about 85,922 (319)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Deep learning for stress oriented human activity recognition. [PDF]

Front Digit Health
Hamza M, Uddin N, Anjum G, Anas M, Gabol U, Saddaf Khan N.   +5 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Clinical Note Generation From Doctor-Patient Conversations Using Parameter-Efficient Fine-Tuning Large Language Models: Comparative Study. [PDF]

JMIR Med Inform
Ahmed S, Yousuf Sadeque F.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Data-Efficient Language Model for Assessing Pulmonary Embolism Diagnostic Certainty From Radiology Reports: Model Development and Validation Study. [PDF]

JMIR Med Inform
Liu F, Hu R, Kim D, Lo H, Kharonov Y, Johri A, Gerber BS, Rundensteiner E, Westafer LM, Allison J, Kiefe C, Bankier A, Rosen MP.   +12 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Advancing Point-of-Care Still's Murmur Identification: Evaluating the Efficacy of ConvNets and Transformers Using the StethAid Multicenter Heart Sound Database. [PDF]

IEEE Trans Biomed Eng
Arjoune Y, Hsu KT, Geggel R, May J, Hovis I, Cosgrove T, Doroshow RW, Shekhar R.   +7 more
europepmc   +1 more source

Improvement of the Sensitivity of Differential Protection of Power Transformers

This paper presents the development of micro-processor based device for improving the sensitivity of differential protection of power transformers. Power transformers failure may lead to high scale system’s operations disruption and heavy economic losses,
Dolgicers, Aleksandrs, Kozadajevs, Jevgeņijs   +1 more
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source