Results 41 to 50 of about 30,712 (194)

Transfusion related acute lung injury in a perinatal woman [PDF]

Journal of Clinical and Scientific Research, 2016
We report the case of a 26-year-old female who underwent emergency caesarean section at a private hospital and was referred to the Government Maternity Hospital (GMH), Tiruapti for bleeding per vaginum 4 hours after delivery. She had received one unit of
Deepthi Krishna G, Sreedhar Babu KV, Arun R, Bharathi T, Jothibai DS   +4 more
doaj   +1 more source

Two-event Transfusion-related Acute Lung Injury Mouse Model

Bio-Protocol, 2015
Transfusion-related acute lung injury (TRALI) is defined as acute lung injury that occurs within 6 hours of a blood product transfusion. TRALI continues to be a leading cause of transfusion-related mortality and we have developed a mouse model of TRALI ...
Guadalupe Ortiz-Muñoz, Mark Looney
doaj   +1 more source

Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice.

PLoS ONE, 2015
Pathogen reduction technology (PRT) has been developed in an effort to make the blood supply safer, but there is controversy as to whether it may induce structural or functional changes to platelets that could lead to acute lung injury after transfusion.
Axelle Caudrillier, Beñat Mallavia, Lindsay Rouse, Susanne Marschner, Mark R Looney   +4 more
doaj   +1 more source

The mystery of transfusion‐related acute lung injury [PDF]

Transfusion, 2011
Transfusion related acute lung injury (TRALI) is a major concern amongst transfusion medicine clinicians and researchers, justly so given its high incidence and sometimes fatal outcome.1 There are a number of mysteries about the syndrome related to mechanisms, diagnosis, treatment and prevention.
Neil, Blumberg, Patricia J, Sime, Richard P, Phipps   +2 more
openaire   +2 more sources

The Pathology of Transfusion-Related Acute Lung Injury [PDF]

American Journal of Clinical Pathology, 1999
Transfusion-related acute lung injury is an uncommon condition characterized by the rapid onset of respiratory distress soon after transfusion. Our understanding of its pathophysiology is based on animal models of complement (C5a) and antibody-induced lung injury and a limited number of autopsies.
S M, Dry, K M, Bechard, E L, Milford, W H, Churchill, R J, Benjamin   +4 more
openaire   +2 more sources

Transfusion-related Acute Lung Injury: A Case Report

Journal of Pediatric Research, 2020
Transfusion-related acute lung injury (TRALI) is a non-cardiac pulmonary edema presenting with severe dyspnea, hypoxia and bilateral diffuse infiltrates on chest X-ray. It usually occurs within the first 6 hours following the administration of plasma and
Arzu Çalışkan Polat, Yeşim Yiğit, Esra Nagehan Akyol Önder, Ayşen Türedi Yıldırım, Pelin Ertan, Hüseyin Gülen   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Acute respiratory distress syndrome in a neonate due to possible transfusion-related acute lung injury

Asian Journal of Transfusion Science, 2017
Transfusion-related acute lung injury (TRALI) is a potentially life-threatening complication of blood component transfusion. It is relatively underdiagnosed entity in neonates with scant literature.
Arti Maria, Sheetal Agarwal, Anu Sharma
doaj   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source