Results 41 to 50 of about 99,595 (215)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Determining the true incidence of acute transfusion reactions: Active surveillance at a specialized liver center

Hematology, Transfusion and Cell Therapy, 2020
Background: Blood transfusion is a life-saving procedure, but may cause adverse transfusion reactions (TRs). The reporting of TRs is often missed due to various reasons. The aim of this study was to determine the incidence of unreported acute TRs through
Ansuman Sahu, Meenu Bajpai
doaj   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Descriptions of acute Transfusion Reactions in the Teaching Hospitals of Kermanshah University of Medical Sciences, Iran

International Journal of Hematology-Oncology and Stem Cell Research, 2013
Background: Transfusion services rely on transfusion reaction reporting to provide patient care and protect the blood supply. Unnecessary discontinuation of blood is a major wastage of scarce blood, as well as man, hours and funds. The aim of the present
Mehrdad Payandeh, Mohammad Erfan Zare, Atefeh Nasir Kansestani, Shirin Falah Pakdel, Firuzeh Jahanpour, Hoshang Yousefi, Farzaneh Soleimanian   +6 more
doaj   +2 more sources

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Transfusion-related adverse reactions: From institutional hemovigilance effort to National Hemovigilance program

Asian Journal of Transfusion Science, 2016
Aims: In this study we have evaluated the various adverse reactions related to transfusion occurring in our institution as a pilot institutional effort toward a hemovigilance program. This study will also help in understanding the problems faced by blood
Rahul Vasudev, Vijay Sawhney, Mitu Dogra, Tilak Raj Raina   +3 more
doaj   +1 more source

The National Clinical Database Risk Calculator and the 5‐Item Modified Frailty Index Predict the Development of Postoperative Delirium After Surgery for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrates that combining the NCD Risk Calculator with the mFI‐5 enables more precise stratification of postoperative delirium risk in patients undergoing surgery for HCC. Patients classified as high risk by the combined model showed a markedly higher incidence of delirium than those in the intermediate‐ and low‐risk groups.
Kiyotaka Hosoda, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Hiroki Sakai, Kentaro Yoshikawa, Tomohiko Ikehara, Hikaru Hayashi, Koya Yasukawa, Yuji Soejima   +9 more
wiley   +1 more source

Characteristics of Acute Transfusion Reactions and its related factors in Cipto Mangunkusumo Hospital Jakarta, Indonesia

Health Science Journal of Indonesia, 2019
Latar belakang: Reaksi transfusi akut (RTA) merupakan sekelompok kejadian yang tidak diinginkan akibat pemberian transfusi darah. Manifestasi dari RTA bervariasi dari yang ringan hingga mengancam nyawa.
Pustika Amalia Wahidiyat, Elida Marpaung, Stephen Diah Iskandar   +2 more
doaj   +1 more source

Alcohol Consumption Is a Risk Factor of Surgical Site Infection After Minimally Invasive Surgery: A Secondary Observational Analysis of a Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
Alcohol consumption was independently associated with Surgical Site Infection in the gastroenterological Minimally Invasive Surgery. Whether preoperative abstinence from alcohol prevents the occurrence of SSI warrants further investigation. ABSTRACT Background Surgical site infection (SSI) is one of the postoperative complications. Risk factors for SSI
Toshiya Akai, Makoto Takeda, Eisuke Booka, Tomohiro Matsumoto, Masayo Takaoka, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi   +9 more
wiley   +1 more source

Lymphocyte‐C‐Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Surgical site infection (SSI) is a major complication after ileal pouch–anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte‐to–C‐reactive protein ratio (LCR), a composite marker of systemic inflammation and immune/nutritional status, has emerged as a potential ...
Yuhki Koike, Koki Higashi, Yuki Sato, Yuka Nagano, Tadanobu Shimura, Takahito Kitajima, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa, Yuji Toiyama   +9 more
wiley   +1 more source