Results 301 to 310 of about 293,415 (335)
Sustained high expression of human FVII following AAV8-mediated gene delivery in mice. [PDF]
Mol Ther Methods Clin DevD'Amico A +9 more
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Viral vectors in neurodegenerative diseases: immune responses and therapeutic applications. [PDF]
Front NeurolWang Y, Mu S, Liu F.
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Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery. [PDF]
Nucleic Acids ResWasserman SR +11 more
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Polycomb-mediated transgenerational epigenetic inheritance of <i>Drosophila</i> eye colour is independent of small RNAs. [PDF]
Open BiolFitz-James M +3 more
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Genome, 1989
Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
openaire +3 more sources
Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
openaire +3 more sources
Current Opinion in Immunology, 1992
The ability of transgenic mice to express a specific protein in a specific tissue has enabled the mechanisms of self-tolerance and autoimmunity to be elucidated. Further studies, combined with more sophisticated methods of gene targeting, will provide insights into the pathway leading from loss of self-tolerance to autoimmunity.
Myung-Shik Lee, Nora Sarvetnick
openaire +3 more sources
The ability of transgenic mice to express a specific protein in a specific tissue has enabled the mechanisms of self-tolerance and autoimmunity to be elucidated. Further studies, combined with more sophisticated methods of gene targeting, will provide insights into the pathway leading from loss of self-tolerance to autoimmunity.
Myung-Shik Lee, Nora Sarvetnick
openaire +3 more sources
Development, Growth & Differentiation, 2012
The development of transgenic chicken technology has lagged far behind that of mammalian species. Two reasons for this are that only a one‐cell‐stage oocyte can be obtained from a sacrificed hen and that the yolk prevents high‐magnification microscopic observation of oocytes.
Ken-ichi Nishijima, Shinji Iijima
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The development of transgenic chicken technology has lagged far behind that of mammalian species. Two reasons for this are that only a one‐cell‐stage oocyte can be obtained from a sacrificed hen and that the yolk prevents high‐magnification microscopic observation of oocytes.
Ken-ichi Nishijima, Shinji Iijima
openaire +3 more sources
Inheritance and expression stability of transgene in transgenic animals
Hereditas (Beijing), 2011Transgenic technology is one of the most hotspots in biology. In the past decade, the progress in animal cloning has provided an alternative method to improve transgenic efficiency. Many kinds of transgenic animals have been successfully produced via the combination of transfection and nuclear transfer.
Qing-Ran Kong, Zhong-Hua Liu
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International Journal of Biochemistry, 1994
1. Although many human therapeutic proteins are currently produced in microbial fermentors using recombinant DNA techniques, it is obvious that microbial processing is not suitable for a large number of bioactive proteins owing to the inability of bacteria to carry out postsynthetic modification reactions required for full biological activity. 2.
J, Jänne +6 more
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1. Although many human therapeutic proteins are currently produced in microbial fermentors using recombinant DNA techniques, it is obvious that microbial processing is not suitable for a large number of bioactive proteins owing to the inability of bacteria to carry out postsynthetic modification reactions required for full biological activity. 2.
J, Jänne +6 more
openaire +2 more sources