Results 301 to 310 of about 361,542 (380)

Selection, counterselection, and conditional gene expression for genetic biocontrol of insects

Insect Science, EarlyView.
Selection, counterselection, and conditional expression can be used for sex separation. Selection (S) and counterselection (CS) genes are linked to the sex chromosomes (e.g., the X and Y chromosomes) to confer sex‐specific selection or counterselection based on the presence or absence of the S or CS genes.
Melanie Hempel, Zhijian Tu
wiley   +1 more source

Speed Breeding Transgenic American Chestnut Trees Toward Restoration. [PDF]

Plant Direct
Klak T, Pilkey H, May VG, Matthews D, Oakes AD, Tan EH, Newhouse AE.   +6 more
europepmc   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

Regulation of therapeutic protein release in response to circadian biomarkers. [PDF]

Nat Commun
Franko N, Li S, Galvan S, Csorba Z, Teixeira AP, Xie M, Fussenegger M.   +6 more
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.

Dis Model Mech
Minakawa EN, Owari K, Nogami N, Nakatani T, Koizumi M, Kawanobe A, Saga Y, Kudo M, Noguchi S, Hanakawa T, Hori Y, Numazawa H, Takeuchi T, Katakai Y, Saito R, Nagai Y, Saito Y, Tomioka I, Seki K.   +18 more
europepmc   +1 more source

A Longitudinal 3D Live-Cell Imaging Platform to Uncover AAV Vector-Host Dynamics at Single-Cell Resolution. [PDF]

Int J Mol Sci
Leysen M, Peredo N, Pavie B, Moeyaert B, Henckaerts E.   +4 more
europepmc   +1 more source

Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy. [PDF]

Mol Ther Methods Clin Dev
Grubor B, Henry KL, Chan SJ, Sheehan M, Shah A, Pellerin A, Bai J, Nadella P, Bommegowda S, Cullen P, Tien E, Chen V, van der Munnik NP, White-Hunt S, Plowey ED, Hamann S, Guise AJ, Xu S, Kirkland M, Doherty J, Lyashenko E, Bhat G, Glajch K, Lo SC, Gianni D, Clarner P, Gagnon J, Chu J, Nambiar K, Lulla M, Zheng F, Weldeab A, Bartlett D, Gutnick A, Reynolds T, Zhu K, Huh D, Carlile TM, Fikes J, Trapa P, Suh J, Morris D, Burkly L.   +42 more
europepmc   +1 more source

The impact of scaRNA12 deregulation on p53‐mediated cellular stress response in B‐cell precursor acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Summary Small nucleolar ribonucleic acids (snoRNAs) are a class of small non‐coding RNAs involved in the post‐transcriptional modification of ribosomal RNAs (rRNA) and small nuclear RNAs (snRNA). Mounting evidence indicates that specific snoRNAs are drivers of oncogenesis, but their role in B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) is ...
Martijn W. C. Verbeek, Mathijs A. Sanders, Dwin G. B. Grashof, Remco M. Hoogenboezem, Iris van Zuijen, Annemarieke Bos, Trui van Gulck, Rosan Olsman, Rishov Mukhopadhyay, Eric M. J. Bindels, Peter J. M. Valk, Harmen J. G. van de Werken, Vincent H. J. van der Velden, Stefan J. Erkeland   +13 more
wiley   +1 more source