Results 301 to 310 of about 360,625 (378)

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

Visualizing DNA repair factor recruitment at sites of transcription in single cells. [PDF]

Chromosome Res
Guan T, Shi Y, Lee TH, Oberdoerffer P.
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs). [PDF]

J Transl Med
Safarzadeh Kozani P, Safarzadeh Kozani P.   +1 more
europepmc   +1 more source

1031. Identification of Hematopoietic Stem Cell (HSC)-Specific microRNAs and Design of Lentiviral Vectors That Detarget Transgene Expression from HSC While Driving It Efficiently in Differentiated Progeny

, 2008

openalex   +1 more source

Versatile molecular tools enabling customizable DNA methylation editing in Arabidopsis. [PDF]

Nat Commun
He L, Yao Y, You Y, Wei X, Ma Y, Yuan W, Lang Z, Zhu JK.   +7 more
europepmc   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Correlation Between Chimeric Antigen Receptor T-Cell Pharmacokinetic Data Measured by Flow Cytometry and Quantitative Polymerase Chain Reaction. [PDF]

Clin Transl Sci
Wang W, Liu X, Yang T, Wang J, Liu J, Wang Y, Yu J, Luo T, Wang X, Li J, Wang C, Chen N, Geng D, Xu D.   +13 more
europepmc   +1 more source

Identification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues

Cell Proliferation, EarlyView.
AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu, Ying Zhang, Wei Li   +11 more
wiley   +1 more source

Evaluation of in vivo CAR transgene levels in tisagenlecleucel-treated patients with relapsed/refractory B-ALL and DLBCL. [PDF]

Blood Adv
Awasthi R, Grupp SA, Waldron ER, Yanik GA, Tam CS, Rives S, McGuirk JP, Pulsipher MA, Jaeger U, Myers GD, Borchmann P, Schuster SJ, Stefanski HE, Bishop MR, Chakraborty A, Masood A, Baruchel A, Waller EK.   +17 more
europepmc   +1 more source