Results 171 to 180 of about 3,746,688 (357)

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

The multiple roles of Ggt1-Cre in the generation of transgenic mice. [PDF]

Cell Mol Biol Lett
Feng ZS, Luo J, Chen XC, Zhao PP, Qiu ST, Wu CY, Huang XR, Sun BC, Guo XJ, Ye ZN, Yang C, Liu HF, Tang JX.   +12 more
europepmc   +1 more source

Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.

Developmental Biology, 2001
Y. Kisanuki, Robert E. Hammer, J. Miyazaki, Clay K. Williams, James A. Richardson, M. Yanagisawa   +5 more
semanticscholar   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Cytosine base editing of LPA in transgenic mice averts large deletions. [PDF]

Mol Ther
Chuecos MA, Park SH, Bhakta MM, Too-Chiobi U, Betancourth D, Cao M, De Giorgi M, Walkey CJ, Tiwari A, Godin B, Assini JM, Palmer DJ, Ng P, Boffa MB, Koschinsky ML, Bao G, Lagor WR.   +16 more
europepmc   +1 more source

HLA class-I-transgenic mice as model system to study MHC-restricted antigen recognition in man [PDF]

, 1990
McMichael, A., G. Riethmüller, A. McMichael, Kievits, F., F. Kievits, G. Brem, Ivanyi, P., C. Botteron, Riethmüller, Gert, Botteron, C., P. Ivanyi, Brem, Gottfried, E. H. Weiss, Schliesser, G., G. Schliesser, Weiss, Elisabeth H.   +15 more
core   +1 more source

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

EMBO Journal, 1991
J. Keffer, L. Probert, Haris Caziaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, G. Kollias   +6 more
semanticscholar   +1 more source