Results 261 to 270 of about 1,952,729 (355)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Protective and curative effects of passive immunization against Amyloid-β protein in APP23 transgenic mice

, 2016
Julia Madeleine Pahl
openalex   +2 more sources

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

High-fat diet activates pyroptosis of retinal pigment epithelial cells in aged TgAPPswePS1 transgenic mice. [PDF]

Eur J Med Res
Cao J, Li J, Zheng H, Dong Z.
europepmc   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Dissecting Sex-Specific Pathology in K18-hACE2 Transgenic Mice Infected With Different SARS-CoV-2 Variants. [PDF]

J Med Virol
Masters EA, Tang W, Kang I, Kosikova M, Hanks JH, Elkins L, Kwon HJ, Ortega-Rodriguez U, Gong B, Mercer KE, Xie H.   +10 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Enhancement of renal fibrosis in PHF20 transgenic mice. [PDF]

Toxicol Res
Juang U, Lee S, Gwon S, Jung W, Nguyen H, Huang Q, Lee B, Kwon SH, Kim SH, Kim IS, Park J.   +10 more
europepmc   +1 more source

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source