Results 261 to 270 of about 3,709,047 (395)

Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice.

, 1989
Masamichi Kimura, Masahiro Sato, Akira Akatsuka, Shiari Nozawa-Kimura, Ryou Takahashi, Maki Yokoyama, T Nomura, Motoya Katsuki   +7 more
openalex   +2 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in <i>Mecp2</i> and <i>Disc1</i> transgenic mice. [PDF]

Sci Adv
Ge Y, Tian T, Li B, Axerio-Cillies P, Chen W, Qin X, Zhao M, Sun QC, Li J, Floresco SB, Liu L, Yang X, Wang YT.   +12 more
europepmc   +1 more source

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Proceedings of the National Academy of Sciences of the United States of America, 1993
I. Campbell, C. Abraham, E. Masliah, Phillip Kemper, J. Inglis, M. Oldstone, L. Mucke   +6 more
semanticscholar   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Immune tolerance induction using the thyrotropin receptor epitope 78-94 (p37) prevents Graves' disease in HLA-DR3 transgenic mice. [PDF]

Front Immunol
Inaba H, Nonaka I, Hashimoto D, Hirono M, Morita S, Kimura H, Iwakura H, Akamizu T, Nakata M.   +8 more
europepmc   +1 more source

Positive Regulatory Elements (HF-1a and HF-1b) and a Novel Negative Regulatory Element (HF-3) Mediate Ventricular Muscle-Specific Expression of Myosin Light-Chain 2-Luciferase Fusion Genes in Transgenic Mice

, 1994
Kevin J. Lee, Reed Hickey, Hong Zhu, Kenneth R. Chien   +3 more
openalex   +2 more sources

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Proceedings of the National Academy of Sciences of the United States of America, 2017
K. Berer, L. Gerdes, Egle Cekanaviciute, Xiaoming Jia, L. Xiao, Z. Xia, Chuan Liu, L. Klotz, U. Stauffer, S. Baranzini, T. Kümpfel, R. Hohlfeld, G. Krishnamoorthy, H. Wekerle   +13 more
semanticscholar   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice. [PDF]

Med Microbiol Immunol
Hsiao NE, Wang YF, Lin YC, Chou WT, Hsu LJ, Wang SM, Wang JR, Lai MD, Chen SH, Chang CF.   +9 more
europepmc   +1 more source