Results 91 to 100 of about 2,621,599 (302)

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]

, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Lubetzki Catherine, Kragh, Christine L, Manuela Neumann, Neumann, Manuela, Lubetzki, Catherine, Bernard Zalc, Glenda M Halliday, Jensen, Poul H, Gai, Wei-Ping, Wei-Ping Gai, Kragh, Christine, Zalc Bernard, Jensen, Poul, Christian Haass, Fillon, Gwenaëlle, Gysbers Amanda, Philipp J Kahle, Richter-Landsberg, Christiane, Fillon Gwenaëlle, Halliday, Glenda M., Hansen, Hanne D, Gwenaëlle Fillon, Gai, Wei Ping, Kragh, Christine L., Hansen, Hanne, Amanda Gysbers, Catherine Lubetzki, Smith, Wanli, Christiane Richter-Landsberg, Kahle Philipp J., Zalc, Bernard, Haass Christian, Richter-Landsberg, Christian, Halliday, Glenda,, Kahle, Philipp J., Kahle, Philipp, Gysbers, Amanda, Hansen, Hanne D., Jensen, Poul H., Richter-Landsberg Christiane, Halliday Glenda M., Kahle, Philipp J, Halliday, Glenda M, Kragh Christine L., Jensen Poul H., Neumann Manuela, Hansen Hanne D., Poul H Jensen, Haass, Christian, Hanne D Hansen, Gai Wei-Ping, Halliday, Glenda, M.   +52 more
core   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Inducible expression of RANKL in transgenic pigs under the control of the Tet-On system [PDF]

, 2011
Because of the tremendous need for transgenic large animal models for human diseases, the process of SCNT is a crucial step in transgenic pig production.
Schilling, Eleonore
core   +1 more source

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants [PDF]

, 2005
Background/Aim: Phenotype-driven screening of a great pool of randomly mutant mice and subsequent selection of animals showing symptoms equivalent to human kidney diseases may result in the generation of novel suitable models for the study of the ...
Tran, T.V., Rathkolb, B., Klempt, M., Wanke, R., Wolf, E., de Angelis, M. H., Aigner, B., Tran, T. V., Hrabě de Angelis, M., Rathkolb, B. ; Tran, T.V. ; Klempt, M. ; Hrabé de Angelis, M. ; Wanke, R. ; Wolf, E. ; Aigner, B.   +9 more
core   +1 more source

Mice Transgenic for the Human Carcinoembryonic Antigen Gene Maintain Its Spatiotemporal Expression Pattern [PDF]

, 1994
The tumor marker carcinoembryonic antigen (CEA) is predominantly expressed in epithelial cells along the gastrointestinal tract and in a variety of adenocarcinomas.
Hirth, Antje, Eades-Perner, Anne-Marie, Neumaier, Michael, Zimmermann, Wolfgang, Putten, Herman van der, Thompson, John A., Kleist, Sabine von   +6 more
core   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]

, 2006
The etiology of Alzheimer’s disease (AD) remains a great challenge for neurological research. Extensive investigations for almost one hundred years have led to profound insights of the pathological and molecular mechanisms that affect the AD brain, and
Ermini, Florian V.
core   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes [PDF]

, 2012
Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Miquel Taron, Jesús M Paramio, Martín Jiménez, Miguel, Pedro Larrañaga, Martínez-Cruz, Ana B., Lorz, Corina, Juan F Aranda, Corina Lorz (145432), Rafael Rosell (145450), García-Escudero Ramón, Santos Mirentxu, Stathopoulos George P., Concha Bielza, Ciruelos, Eva M., Mirentxu Santos, Dahabreh Jubrail, Ana B Martínez-Cruz, Bielza Concha, George P. Stathopoulos (145448), Pedro Larrañaga (145444), Aranda Juan F., Marta Dueñas, Rodríguez-Peralto José L., Corina Lorz, Rosell, Rafael, Martínez-Cruz Ana B., Lorz Corina, Dueñas Marta, Marta Dueñas (145419), Taron Miquel, Miquel Taron (145434), Santos, Mirentxu, Larrañaga Pedro, Dueñas, Marta, Jubrail Dahabreh, Ramón García-Escudero, José L Rodríguez-Peralto, Ana B. Martínez-Cruz (145430), Eva M Ciruelos, Rosell Rafael, Dahabreh, Jubrail, Jesús M. Paramio (145453), Miguel Martín, José L. Rodríguez-Peralto (145441), Larrañaga Múgica, Pedro María, Ciruelos Eva M., Ramón García-Escudero (3914537), Eva M. Ciruelos (145438), Taron, Miquel, Paramio, Jesús M., Juan F. Aranda (145425), Jubrail Dahabreh (145446), García-Escudero, Ramón, Martín Miguel, Paramio Jesús M., Aranda, Juan F., George P Stathopoulos, Bielza, Concha, Miguel Martín (3443171), Stathopoulos, George P., Larrañaga Múgica, Pedro, Mirentxu Santos (145422), Concha Bielza (145428), Rodríguez-Peralto, José L., Rafael Rosell   +64 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source