Results 51 to 60 of about 4,008,952 (354)

Arabidopsis and Brachypodium distachyon Transgenic Plants Expressing Aspergillus nidulans Acetylesterases Have Decreased Degree of Polysaccharide Acetylation and Increased Resistance to Pathogens1[C][W][OA]

Plant Physiology, 2013
Acetylation of the cell wall affects plant resistance to pathogens. The plant cell wall has many significant structural and physiological roles, but the contributions of the various components to these roles remain unclear.
G. Pogorelko, Vincenzo Lionetti, O. Fursova, R. Sundaram, M. Qi, S. Whitham, A. Bogdanove, D. Bellincampi, O. Zabotina   +8 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Elevated methionine content in soybean seed by overexpressing maize β-zein protein

Oil Crop Science, 2020
Soybean provides superior and readily available protein for human and livestock. However, nutritional value of soybean is limited due to the deficiency of an essential amino acid, methionine.
Chen Guo, Xiujie Liu, Li Chen, Yupeng Cai, Weiwei Yao, Shan Yuan, Cunxiang Wu, Tianfu Han, Shi Sun, Wensheng Hou   +9 more
doaj  

Expression of Bt Protein in Transgenic Bt Cotton Plants and Ecological Fitness of These Plants in Different Habitats

Frontiers in Plant Science, 2020
Fitness is one of the key parameters to evaluate the effects of transgenic plants on the ecological environment. To evaluate the ecological risk of transgenic Bt cotton plants growing in different habitats, we determined the expression of the exogenous ...
Laipan Liu, Laipan Liu, Ruqing Guo, Qin Qin, Jianmei Fu, Biao Liu, Biao Liu   +6 more
doaj   +1 more source

Less is more: strategies to remove marker genes from transgenic plants

BMC Biotechnology, 2013
Selectable marker genes (SMGs) and selection agents are useful tools in the production of transgenic plants by selecting transformed cells from a matrix consisting of mostly untransformed cells.
Yuan-Yeu Yau, C. Neal, Stewart Jr
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Transcriptome and metabolome analyses reveal the regulatory role of MdPYL9 in drought resistance in apple

BMC Plant Biology
Background The mechanisms by which the apple MdPYL9 gene mediates the response to drought stress remain unclear. Here, transcriptome and metabolome analyses of apple plants under drought were used to investigate the mechanisms by which MdPYL9 regulates ...
Mingxiao Liu, Yitong Liu, Wei Hu, Baoying Yin, Bowen Liang, Zhongyong Li, Xueying Zhang, Jizhong Xu, Shasha Zhou   +8 more
doaj   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Enhanced Whitefly Resistance in Transgenic Tobacco Plants Expressing Double Stranded RNA of v-ATPase A Gene

PLoS ONE, 2014
Background Expression of double strand RNA (dsRNA) designed against important insect genes in transgenic plants have been shown to give protection against pests through RNA interference (RNAi), thus opening the way for a new generation of insect ...
N. Thakur, Santosh Kumar Upadhyay, P. Verma, K. Chandrashekar, R. Tuli, Pradhyumna K. Singh   +5 more
semanticscholar   +1 more source