Results 71 to 80 of about 27,839 (297)

High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of NCED4 in Lettuce (Lactuca sativa). [PDF]

, 2018
CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary transformants. However, many of the mutations analyzed were somatic and therefore not heritable.
Bertier, Lien D, Bradford, Kent J, Britt, Anne B, Huo, Heqiang, Michelmore, Richard W, Ron, Mily   +5 more
core   +2 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza?

Viruses, 2018
Influenza A virus (IAV) represents an ongoing threat to human and animal health worldwide. The generation of IAV-resistant chickens through genetic modification and/or selective breeding may help prevent viral spread.
Fong Yang Looi, Michelle L. Baker, Thomas Townson, Mathilde Richard, Ben Novak, Tim J. Doran, Kirsty R. Short   +6 more
doaj   +1 more source

Aldo-keto reductase-1 (AKR1) protect cellular enzymes from salt stress by detoxifying reactive cytotoxic compounds [PDF]

, 2017
Cytotoxic compounds like reactive carbonyl compounds such as methylglyoxal (MG), melandialdehyde (MDA), besides the ROS accumulate significantly at higher levels under salinity stress conditions and affect lipids and proteins that inhibit plant growth ...
Amarnatha Reddy, V., Babitha, K.C., Sarangi, S.K., Solanki, J.K., Udayakumar, M., Vemanna, R.S.   +5 more
core   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

A revolução verde e a biologia molecular The green revolution and the molecular biology

Revista de Ciências Agrárias, 2009
No virar deste século foram identificados os genes responsáveis pela redução da estatura das variedades de trigo e de arroz que possibilitaram a chamada Revolução Verde dos anos sessenta.
Fernando Santos Henriques
doaj  

Germline Transgenic Methods for Tracking Cells and Testing Gene Function During Regeneration in the Axolotl

, 2013
The salamander is the only tetrapod that regenerates complex body structures throughout life. Deciphering the underlying molecular processes of regeneration is fundamental for regenerative medicine and developmental biology, but the model organism had ...
Khattak, Shahryar, Schuez, Maritta, Richter, Tobias, Knapp, Dunja, Haigo, Saori L., Sandoval-Guzmán, Tatiana, Hradlikova, Kristyna, Duemmler, Annett, Kerney, Ryan R., Tanaka, Elly M.   +9 more
core   +3 more sources

Altered expression of maize PLASTOCHRON1 enhances biomass and seed yield by extending cell division duration [PDF]

, 2017
Maize is the highest yielding cereal crop grown worldwide for grain or silage. Here, we show that modulating the expression of the maize PLASTOCHRON1 (ZmPLA1) gene, encoding a cytochrome P450 (CYP78A1), results in increased organ growth, seedling vigour,
Cahill, James, Claeys, Hannes, Coussens, Griet, De Block, Jolien, De Vliegher, Alex, Delbare, Sofie, Demuynck, Kirin, Feys, Kim, Inzé, Dirk, Ljung, Karin, Muszynski, Michael, Nelissen, Hilde, Novak, Ondrej, Storme, Veronique, Sun, Xiaohuan, Van Hautegem, Tom, Van Lijsebettens, Maria, Versteele, Charlot, Whipple, Clinton   +18 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source