Results 71 to 80 of about 17,611 (257)

Recent Advances in Transparent Microelectrode Device Architecture and Fabrication Strategies for Biomedical Applications

open access: yesAdvanced Materials Technologies, EarlyView.
Transparent microelectrode arrays enable simultaneous optical and electrical electrophysiology with high spatiotemporal resolution, allowing multimodal observations of dynamic biological systems. Advances in materials and device architectures improve device performance by addressing key trade‐offs between optical transparency, impedance, and ...
Michael Abraham Listyawan   +6 more
wiley   +1 more source

A revolução verde e a biologia molecular The green revolution and the molecular biology

open access: yesRevista de Ciências Agrárias, 2009
No virar deste século foram identificados os genes responsáveis pela redução da estatura das variedades de trigo e de arroz que possibilitaram a chamada Revolução Verde dos anos sessenta.
Fernando Santos Henriques
doaj  

Comparisons of physiological indices related to abiotic stress response of TaNAC67 transgenics under normal or/and stress conditions.

open access: yes, 2014
A. Most TaNAC67 transgenics had higher chlorophyll contents relative to control plants under salt stress. Values are means ± SE (n = 20 plants). *,** significantly different from WT at P = 0.05, 0.01, respectively. B. TaNAC67 transgenics had higher water
Shuangshuang Chen (508234)   +4 more
core   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza?

open access: yesViruses, 2018
Influenza A virus (IAV) represents an ongoing threat to human and animal health worldwide. The generation of IAV-resistant chickens through genetic modification and/or selective breeding may help prevent viral spread.
Fong Yang Looi   +6 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

open access: yesAdvanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang   +13 more
wiley   +1 more source

Molecular biology of the kallikrein-kinin system: from structure to function

open access: yesBrazilian Journal of Medical and Biological Research, 1998
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj   +1 more source

Southern blot analysis.

open access: yes, 2015
Southern blot analysis of rol B (a) and rol C transgenic lines (b). TB1-TB4 represents rol B transgenics whereas TC1-TC3 represent rol C transgenics. Whereas "P” stands for the plasmid DNA run as positive control. WT indicates the wild type plant.
Karla Ramirez Estrada (804539)   +4 more
core   +1 more source

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