Results 221 to 230 of about 1,867,403 (306)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

On the within-person effects of political attitudes on outgroup animosity: Evidence for Democratic-Republican asymmetry. [PDF]

PLoS One
Schul Y, Ganzach Y, Pazy A.
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Multi-spatiotemporal projection enables single-shot ultrafast compressed imaging. [PDF]

Light Sci Appl
Lai Y, Liang J.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Deep-Learning-Based Scoring Framework for Large-Scale Multi-donor Cardiotoxicity Screening. [PDF]

Comput Struct Biotechnol J
Vu D, Kowalczewski A, Burnett SD, Sakolish C, Liu X, Yang H, Rusyn I, Ma Z.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Deciphering Femtosecond Charge-Lattice Dynamics in Textured LaFeO3 Thin Films. [PDF]

ACS Nano
Lazemi M, Mohammad FJ, Ash R, Abhari Z, Candela R, Blankesteijn HJFA, van der Minne E, Birkhölzer YA, Segovia Guzmán M, Nunnenkamp M, Le PTP, Park SH, Katoch A, Kwon S, Baeumer C, Koster G, Rouzée A, Bergmann U, de Groot FMF.   +18 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Role of Transport Polarity in Transient Electroluminescence of Two-Dimensional TMDC Semiconductors. [PDF]

Nanomaterials (Basel)
Yang X, Liu K, Huang R, Zou Z, Zhu C, Jiang F, Chen Y, Zhang Y, Shan L.   +8 more
europepmc   +1 more source