Results 61 to 70 of about 1,208,908 (269)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Double slapping effects on a supercavitation projectile

open access: yesAIP Advances, 2019
Based on the theory of rigid body kinematics, a double slapping theoretical model is established for supercavitation projectile. And a parabolic simplification model is used for replacing the supercavitation equation in the part region of the cavity ...
Kangjian Wang   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Design and manufacture of a 100 kA coaxial pulsed power cable for plasma generator and PPS in ETC guns

open access: yesDefence Technology, 2019
Based on our previous pulsed current and internal overvoltage test data and the experience of common commercial high power cables, a 100 kA coaxial pulsed power cable is designed and manufactured to adapt the coaxial electric energy breech transmission ...
Yong Jin   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Simulation of two-dimensional interior ballistics model of solid propellant electrothermal-chemical launch with discharge rod plasma generator

open access: yesDefence Technology, 2017
Instead of the capillary plasma generator (CPG), a discharge rod plasma generator (DRPG) is used in the 30 mm electrothermal-chemical (ETC) gun to improve the ignition uniformity of the solid propellant.
Yan-jie Ni   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Transient congenital hypothyroidism – too short to be transient

open access: yesJournal of Postgraduate Medicine, 2021
Congenital hypothyroidism (CH) occurs due to thyroid dysgenesis, thyroid ectopy, and dyshormonogenesis. A proportion of CH is transient which might be due to iodine deficiency/excess or maternal antibody-mediated. Certain forms of dyshormonogenetic defects may cause transient hypothyroidism.
openaire   +2 more sources

Robustness of Supercavitating Vehicles Based on Multistability Analysis

open access: yesAdvances in Mathematical Physics, 2017
Supercavity can increase speed of underwater vehicles greatly. However, external interferences always lead to instability of vehicles. This paper focuses on robustness of supercavitating vehicles.
Yipin Lv   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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