Results 131 to 140 of about 1,104,045 (310)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development and Verification of a Transient Analysis Tool for Solar Power Tower System with sCO₂ Brayton Cycle

Energies
Supercritical carbon dioxide (sCO2) Brayton cycle is a promising technology for concentrating solar power systems. However, existing studies predominantly rely on steady-state or quasi-steady-state assumptions, thereby neglecting transient ...
Chenxu Xu, Jichen Zou, Gang Wang, Chuntian Gao   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Pseudo-transient computational fluid dynamics analysis of an underbonnet compartment during thermal soak

, 2007
Underbonnet simulations are proving to be crucially important within a vehicle development programme, reducing test work and time-to-market. While computational fluid dynamics (CFD) simulations of steady forced flows have been demonstrated to be reliable,
Franchetta, M., Suen, K.O., Bancroft, T.G.   +2 more
core  

Numerical Simulation of Heat Transfer Behavior of Dissimilar AA5052-AA6061 Plates in Fiction Stir Welding: An Experimental Validation

Journal of Mechanical Engineering, 2019
Fiction Stir welding (FSW) a unique type of metal joining process in solid state, where the heat generation takes place due to the friction action between the rotating tool and the work piece.
Vishwanath M. M., Lakshamanaswamy N., Ramesh G. K.   +2 more
doaj   +1 more source

Magnetic Barkhausen Noise Transient Analysis for Microstructure Evolution Characterization with Tensile Stress in Elastic and Plastic Status. [PDF]

Sensors (Basel), 2021
Liu J, Tian G, Gao B, Zeng K, Liu Q, Zheng Y.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reduction of the Measurement Time of a Chemiresistive Gas Sensor Using Transient Analysis and the Cantor Pairing Function. [PDF]

ACS Meas Sci Au, 2022
Kanaparthi S, Singh SG.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cochlear Hearing Loss Detection System Based on Transient Evoked Otoacoustic Emissions

, 2004
The aim of this paper is to evaluate the application of the discrete wavelet transform (DWT) and support vector machines (SVM) to transient evoked otoacoustic emissions (TEOAE) in order to achieve a detection of frequency-specific hearing loss (HL).We ...
Weiss, Stephan, Dietl, H., Weiss, S., Dietl, Hubert   +3 more
core