FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Novel Approach for Rate Transient Analysis of Fractured Wells from Carbonate Reservoirs with Heterogeneous Natural Fractures. [PDF]
ACS Omega, 2023 Tang H +7 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
PSpice Modeling of a Sandwich Piezoelectric Ceramic Ultrasonic Transducer in Longitudinal Vibration
Sensors, 2017 Sandwiched piezoelectric transducers are widely used, especially in high power applications. For more convenient analysis and design, a PSpice lossy model of sandwiched piezoelectric ultrasonic transducers in longitudinal vibration is proposed by means ...
Xiaoyuan Wei +3 more
doaj +1 more source
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes. [PDF]
Circ Res, 2021 Psaras Y +15 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Semi-analytical solution for bottomhole pressure transient analysis of a hydraulically fractured horizontal well in a fracture-cavity reservoir. [PDF]
Sci Rep, 2022 Hailong L.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Code Development for System Design and Analysis of Megawatt-level Space Nuclear Power System
Yuanzineng kexue jishuThe space nuclear power system, which integrates a gas-cooled reactor with a closed Brayton cycle, is a leading candidate for megawatt-level aerospace power system due to its high efficiency, substantial power output, and independence from sunlight ...
JIANG Baihui, JI Yu, SUN Jun, SHI Lei
doaj +1 more source