Results 101 to 110 of about 855,147 (298)

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

open access: yesFEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu   +4 more
wiley   +1 more source

Techniques to Understand Computer Simulations: Markov Chain Analysis [PDF]

open access: yes
The aim of this paper is to assist researchers in understanding the dynamics of simulation models that have been implemented and can be run in a computer, i.e. computer models.
José Manuel Galán   +3 more
core  

Transient Typechecks are (Almost) Free [PDF]

open access: yesarXiv, 2018
Transient gradual typing imposes run-time type tests that typically cause a linear slowdown in programs' performance. This performance impact discourages the use of type annotations because adding types to a program makes the program slower. A virtual machine can employ standard just-in-time optimizations to reduce the overhead of transient checks to ...
arxiv  

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

PQ TREES, CONSECUTIVE ONES PROBLEM AND APPLICATIONS [PDF]

open access: yes, 2008
A PQ tree is an advanced tree–based data structure, which represents a family of permutations on a set of elements. In this research article, we considered the significance of PQ trees and the Consecutive ones Problem to Computer Science and ...
Adebiyi, E. F.   +3 more
core  

Blast: a Web Application for Characterizing the Host Galaxies of Astrophysical Transients [PDF]

open access: yesarXiv
Characterizing the host galaxies of astrophysical transients is important to many areas of astrophysics, including constraining the progenitor systems of core-collapse supernovae, correcting Type Ia supernova distances, and probabilistically classifying transients without photometric or spectroscopic data.
arxiv  

Optimizing and Evaluating Transient Gradual Typing [PDF]

open access: yesarXiv, 2019
Gradual typing enables programmers to combine static and dynamic typing in the same language. However, ensuring a sound interaction between the static and dynamic parts can incur significant runtime cost. In this paper, we perform a detailed performance analysis of the transient gradual typing approach implemented in Reticulated Python, a gradually ...
arxiv  

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

open access: yesFEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

open access: yesFEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti   +5 more
wiley   +1 more source

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