Results 81 to 90 of about 9,055 (284)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Computer Program Manual: Transient Model of Hydrogen/Oxygen Reactor

, 1971
Computer programming manual for calculating temperature and reactant concentrations as functions of time and axial position in catalyzed continuous flow hydrogen-oxygen ...
Kesten, A. S., Smith, E. J.
core  

Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers

, 2019
© 2016 Elsevier Inc. Generic spinal motor neuron identity is established by cooperative binding of programming transcription factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers.
Tan, G. Christopher, Tan, G Christopher, Bashkirova, Elizaveta V, Gifford, David K., Gifford, David K, Closser, Michael, Guo, Yuchun, Wichterle, Hynek, Bashkirova, Elizaveta V., Rhee, Ho Sung   +9 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

DeSyRe: on-Demand System Reliability

, 2013
The DeSyRe project builds on-demand adaptive and reliable Systems-on-Chips (SoCs). As fabrication technology scales down, chips are becoming less reliable, thereby incurring increased power and performance costs for fault tolerance. To make matters worse,
Vavouras, M, Malek, A., Gaydadjiev, G. N., Shafik, Rishad Ahmed, Rauwerda, G., Pnevmatikatos, Dionisios N, Bouganis, Christos-Savvas, Armato, A.,, Pnevmatikatos, Dionisios N.,, Armato, Antonino, Strydis, C., Vavouras, Michail, Theodoropoulos, Dimitris, Armato, A, Pnevmatikatos, D, Mariani, Riccardo, Shafik, R. A., Tzilis, S., Falsafi, B., Theodoropoulos, D., Malek, A, Pradhan, D.K.,, Pnevmatikatos, D., Sourdis, Ioannis,, Shafik, R.A., Shafik, R.A.,, Tzilis, S, Pradhan, D.K., Rauwerda, Gerard, Pnevmatikatos, D.N., Bouganis, C.S., Armato, A., Pradhan, Dhiraj K, Sourdis, I., Sunesen, Kim, Pradhan, D. K., Sourdis, Ioannis, Rauwerda, G, Falsafi, B, Gaydadjiev, Georgi,, Mariani, R, Shafik, RA, Seepers, Robert, Rauwerda, G.K., Seepers, R. M., Gaydadjiev, Georgi N., Theodoropoulos, D, Sunesen, K, Strydis, Christos, Rauwerda, G.K.,, Bouganis, CS, Bouganis, C. S., Tzilis, Stavros, Pnevmatikatos, Dionisios N., Falsafi, B.,, Mariani, R., Seepers, R.M., Sunesen, K., Sunesen, K.,, Theodoropoulos, D.,, Bouganis, C. S.,, Pradhan, DK, Isaza, S., Sourdis, I, Isaza, S, Gaydadjiev, GN, Mariani, R.,, Vavouras, M., Tzilis, Stavros,, Gaydadjiev, Georgi, Isaza, Sebastian, Malek, Alirad, Malek, Alirad,, Vavouras, M.,, Falsafi, Babak, Strydis, Christos; id_orcid   +75 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Investigation of a piezo-polymer array transducer for pulse-echo ultrasonic material examinations [PDF]

, 1992
The aim of this investigation was to make a flexible array of pulse-echo ultrasound transducers by etching two orthogonal linear arrays of conducting elements into the metallisation of either side of a sheet of PVdF.
Tyler, N. J.
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A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Perform - A performance optimizing computer program for dynamic systems subject to transient loadings

, 1973
A description and applications of a computer capability for determining the ultimate optimal behavior of a dynamically loaded structural-mechanical system are presented.
Clark, B., Pilkey, W. D., Yoo, Y., Wang, B. P.   +3 more
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