Results 121 to 130 of about 884,094 (296)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Solving three core challenges in transient dynamics analysis of matrix population models

Methods in Ecology and Evolution
Populations are at the mercy of random disturbances, large and small, and rarely, if ever, converge on predicted long‐term behaviours. Therefore, when using matrix population models, ecologists study the dynamics of populations that depart from stable ...
Richard A. Hinrichsen
doaj   +1 more source

Projecting regional climate and cropland changes using a linked biogeophysical‐socioeconomic modeling framework: 2. Transient dynamics

Journal of Advances in Modeling Earth Systems, 2017
Understanding climate‐cropland interactions and their impact on future projections in West Africa motivated the recent development of a modeling framework that asynchronously couples four models for regional climate, crop growth, socioeconomics, and ...
Kazi Farzan Ahmed, Guiling Wang, Liangzhi You, Richard Anyah, Chuanrong Zhang, Amy Burnicki   +5 more
doaj   +1 more source

Turbulence near cyclic fold bifurcations in birhythmic media

, 2004
We show that at the onset of a cyclic fold bifurcation, a birhythmic medium composed of glycolytic oscillators displays turbulent dynamics. By computing the largest Lyapunov exponent, the spatial correlation function, and the average transient lifetime ...
A. Goldbeter, Dorjsuren Battogtokh, G. Zubay, H. Mori, J. Mohberg, John J. Tyson, K. Chen, K. Nozaki, M. I. Rabinovich, M. T. Borisuk, Y. Kuramoto   +10 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Transient Dynamics and Thermal Stress for Nuclear Rocket Heat-exchanger [PDF]

Transient dynamics and thermal stresses in nuclear rocket heat ...
Liu, T. C., Shen, C. N.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Transient dynamics of quasinormal mode sums

Journal of High Energy Physics
Quasinormal modes of spacetimes with event horizons are typically governed by a non-normal operator. This gives rise to spectral instabilities, a topic of recent interest in the black hole pseudospectrum programme. In this work we show that non-normality
Javier Carballo, Benjamin Withers
doaj   +1 more source

Unraveling Spatiotemporal Transient Dynamics at the Nanoscale via Wavelet Transform-Based Kelvin Probe Force Microscopy. [PDF]

ACS Nano, 2023
Biglarbeigi P, Morelli A, Pauly S, Yu Z, Jiang W, Sharma S, Finlay D, Kumar A, Soin N, Payam AF.   +9 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source