Results 51 to 60 of about 247,695 (263)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Virtual oscillator with delayed feedback for transient mitigation in inverter-based islanded microgrids

International Journal of Renewable Energy Development
In recent years, the conventional control schemes for renewable energy-based inverter-dominated microgrids have been expeditiously replaced by Virtual Oscillator-based Control (VOC).
Sanjna Salim, Chembathu Ayyappan Babu, Bindu Murali Krishna   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

How can we augment the few that remain? Using stable population dynamics to aid reintroduction planning of an iteroparous species [PDF]

PeerJ, 2019
Restoration of depleted populations is an important method in biological conservation. Reintroduction strategies frequently aim to restore stable, increasing, self-sustaining populations.
Brenda J. Hanley, Elizabeth M. Bunting, Krysten L. Schuler   +2 more
doaj   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ultrafast transient dynamics in composite multiferroics

New Journal of Physics, 2016
We investigate theoretically the dynamic multiferroic (MF) response of coupled ferroelectric (FE)/ferromagnetic (FM) composites upon excitation by a photo-induced acoustic strain pulse. Two magnetoelectric (ME) mechanisms are considered: interface strain-
Chenglong Jia, Ning Zhang, Alexander Sukhov, Jamal Berakdar   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

State space analysis of diphtheria pathogenesis using semi-tensor products and permutation methods [PDF]

Network Biology
In this study, we analyze the state space of a Boolean network modeling diphtheria pathogenesis, focusing on key genes such as Tox, Rep, INF1/INF2, TLR, AP1, IL6, and TNF.
Ugbene Ifeanyichukwu Jeff, Ighovotueko Sophia Ajuremisan   +1 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Simulation study on impact characteristics of RF microsystem based on bulk silicon MEMS process

Dianzi Jishu Yingyong
The high overload impact test is costly and time consuming, and the failure detection means are few, so it is difficult to locate the weak points of the structure. In this paper the impact response spectrum and transient dynamics method are used to study
Feng Zhengsen, Wang Lu, Zeng Yanping, Yang Bing, Qi Dong, Wang Zhihui, Zhang Rui   +6 more
doaj   +1 more source