Results 41 to 50 of about 6,370,880 (242)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Optimal design and experimental validation of 3D C/SiC-TC4 hybrid lattice structures with lightweight, thermal insulation, and excellent mechanical properties

Results in Engineering
With the development of aerospace spacecrafts (hypersonic vehicle), the strong airflow and ultra-high temperature environment encountered during service are more complex.
Mengzhou Chang, Wenbin Ma, Feigao Fan, Lulu Li, Kai Guo, Enling Tang   +5 more
doaj   +1 more source

An improved thermal jet for the propellant launching system

Case Studies in Thermal Engineering, 2023
This work is focused to study the energy release and flow behavior of liquid propellant during internal ballistics cycle of liquid launching system on the base of the thermal gas jet.
Xiaochun Xue, Yonggang Yu
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Data-driven modeling of geometry-adaptive steady heat conduction based on convolutional neural networks

Case Studies in Thermal Engineering, 2021
A data-driven model for rapid prediction of the steady-state heat conduction of a hot object with arbitrary geometry is developed. Mathematically, the steady-state heat conduction can be described by the Laplace's equation, where a heat (spatial ...
Jiang-Zhou Peng, Xianglei Liu, Nadine Aubry, Zhihua Chen, Wei-Tao Wu   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Macro Meso Response and Stress Wave Propagation Characteristics of MCT High-Voltage Switch Under Shock load

Defence Technology
In order to study the dynamic and electrical coupling response characteristics of Metal Oxide Semiconductor Controlled Thyristor (MCT) high-voltage switch under the synergic action of mechanical load and high voltage, the separated Hopkinson pressure bar
Yuyang Guo, Chuang Chen, Ruizhi Wang, Enling Tang   +3 more
doaj   +1 more source

Data-Driven Modeling of Geometry-Adaptive Steady Heat Convection Based on Convolutional Neural Networks

Fluids, 2021
Heat convection is one of the main mechanisms of heat transfer, and it involves both heat conduction and heat transportation by fluid flow; as a result, it usually requires numerical simulation for solving heat convection problems.
Jiang-Zhou Peng, Xianglei Liu, Zhen-Dong Xia, Nadine Aubry, Zhihua Chen, Wei-Tao Wu   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Numerical simulation of cavitation and ballistic characteristics of underwater electromagnetically launching projectiles in the shear crossflow [PDF]

AIP Advances
The electromagnetic launch during underwater navigation is affected by the flow field around ships, and the crossflow velocity presents a boundary-layer distribution under the shear effect of the ship walls.
Ziyi Liu, Yunxia Xu, Xin Zhang, Wenbin Feng, Qianye Ren, Xinyue Cao, Sinuo Chen, Qi Dai   +7 more
doaj   +1 more source