Results 51 to 60 of about 297,414 (264)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multi-Physics Coupling Parameter Analysis of TiZrHf Medium Entropy Alloy

Metals
The complex coupling relationships among the thermal, mechanical, and electrical physical parameters of TiZrHf-based medium-entropy alloys represent a key factor restricting their practical applications under complex extreme environments.
Mengzhou Chang, Bo Wang, Chuang Chen, Enling Tang   +3 more
doaj   +1 more source

Data-driven modeling of geometry-adaptive steady heat conduction based on convolutional neural networks

Case Studies in Thermal Engineering, 2021
A data-driven model for rapid prediction of the steady-state heat conduction of a hot object with arbitrary geometry is developed. Mathematically, the steady-state heat conduction can be described by the Laplace's equation, where a heat (spatial ...
Jiang-Zhou Peng, Xianglei Liu, Nadine Aubry, Zhihua Chen, Wei-Tao Wu   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Data-Driven Modeling of Geometry-Adaptive Steady Heat Convection Based on Convolutional Neural Networks

Fluids, 2021
Heat convection is one of the main mechanisms of heat transfer, and it involves both heat conduction and heat transportation by fluid flow; as a result, it usually requires numerical simulation for solving heat convection problems.
Jiang-Zhou Peng, Xianglei Liu, Zhen-Dong Xia, Nadine Aubry, Zhihua Chen, Wei-Tao Wu   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimal design and experimental validation of 3D C/SiC-TC4 hybrid lattice structures with lightweight, thermal insulation, and excellent mechanical properties

Results in Engineering
With the development of aerospace spacecrafts (hypersonic vehicle), the strong airflow and ultra-high temperature environment encountered during service are more complex.
Mengzhou Chang, Wenbin Ma, Feigao Fan, Lulu Li, Kai Guo, Enling Tang   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Macro Meso Response and Stress Wave Propagation Characteristics of MCT High-Voltage Switch Under Shock load

Defence Technology
In order to study the dynamic and electrical coupling response characteristics of Metal Oxide Semiconductor Controlled Thyristor (MCT) high-voltage switch under the synergic action of mechanical load and high voltage, the separated Hopkinson pressure bar
Yuyang Guo, Chuang Chen, Ruizhi Wang, Enling Tang   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source