Results 91 to 100 of about 168,749 (376)

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Multimorbidity, functional impairment, and mortality in older patients stable after prior acute myocardial infarction: Insights from the TIGRIS registry

Clinical Cardiology, Volume 45, Issue 12, Page 1277-1286, December 2022., 2022
Abstract Background Data on the association of multimorbidity and functional impairment with cardiovascular (CV) and non‐CV outcomes among older myocardial infarction (MI) patients are limited. Hypothesis Multimorbidity and functional impairment among older MI patients are associated with CV and non‐CV mortality.
Akshay Bagai, Faeez M. Ali, John Gregson, Karen P. Alexander, Mauricio G. Cohen, Karolina Andersson Sundell, Tabassome Simon, Dirk Westermann, Satoshi Yasuda, David Brieger, Shaun G. Goodman, Jose C. Nicolau, Christopher B. Granger, Stuart Pocock   +13 more
wiley   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Use of lipid‐lowering therapies in patients with chronic kidney disease and atherosclerotic cardiovascular disease: 2‐year results from Getting to an imprOved Understanding of Low‐Density lipoprotein cholesterol and dyslipidemia management (GOULD)

Clinical Cardiology, Volume 45, Issue 12, Page 1303-1310, December 2022., 2022
Abstract Background Chronic kidney disease (CKD) is a known risk factor of atherosclerotic cardiovascular disease (ASCVD). Per the 2018 American Heart Association/American College of Cardiology cholesterol guidelines, high‐risk ASCVD patients with CKD and low‐density lipoprotein cholesterol (LDL‐C) levels ≥ $\ge $ 70 mg/dL should take a high‐intensity ...
Aleesha Shaik, Mikhail Kosiborod, James A. de Lemos, Qi Gao, Katherine E. Mues, Shushama Alam, Deepak L. Bhatt, Christopher P. Cannon, Christie M. Ballantyne, Robert S. Rosenson, The GOULD Investigators   +10 more
wiley   +1 more source

Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack

International Journal of Stroke, 2018
Background Previous studies suggested that enlarged perivascular spaces are neuroimaging markers of cerebral small vessel disease. However, it is not clear whether enlarged perivascular spaces are associated with cognitive impairment.
F. Arba, T. Quinn, G. Hankey, K. Lees, J. Wardlaw, Myzoon Ali, D. Inzitari   +6 more
semanticscholar   +1 more source

Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

Advanced Science, EarlyView.
Postoperative cognitive dysfunction (POCD) remains a challenge with no effective treatments. This study introduces a novel hydrogen‐gene therapy strategy, combining focused ultrasound and siRNA delivery via hydrogen emitters, to repair neuroinflammation in a precise and controlled manner.
Ruonan Zhan, Yan Fang, Chuyun Lou, Nan Chen, Xuan Mo, Bo Jiao, Mengke Liu, Yangxi Zhao, Weichen Xu, Huixiong Xu, Haohao Yin, Yi Zhang   +11 more
wiley   +1 more source

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack.

New England Journal of Medicine, 2016
BACKGROUND Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia.
S. Johnston, P. Amarenco, G. Albers, H. Denison, J. Easton, Scott R. Evans, P. Held, Jenny Jonasson, K. Minematsu, Carlos A. Molina, Yongjun Wang, K. S. L. Wong   +11 more
semanticscholar   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

An update and review of narrowband ultraviolet B phototherapy for vitiligo

Dermatological Reviews, Volume 3, Issue 5, Page 326-335, October 2022., 2022
Abstract Vitiligo is a chronic skin condition that results in depigmentation. It affects up to 2% of the population worldwide. Phototherapy is one of the most commonly used treatment methods for vitiligo. In the last few decades, there has been an increasing popularity of narrowband ultraviolet B phototherapy (NB‐UVB) over other forms of phototherapy ...
Eugene Wang, Michelle Rodrigues
wiley   +1 more source

Prescription smoking-cessation medication pharmacy claims after stroke and transient ischemic attack

Preventive Medicine Reports, 2022
Smoking cessation is critical in secondary prevention after stroke and transient ischemic attack. Data regarding use of smoking-cessation interventions after stroke and transient ischemic attack are sparse.
Neal S. Parikh, Yongkang Zhang, Daniel Restifo, Erika Abramson, Matthew J. Carpenter, Babak B. Navi, Hooman Kamel   +6 more
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