Results 291 to 300 of about 177,769 (383)

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

open access: yesInterdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen   +12 more
wiley   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

open access: yesInterdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang   +6 more
wiley   +1 more source

Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy

open access: yesJournal of Biophotonics, EarlyView.
Brillouin spectroscopy distinguishes fibrotic from healthy tissue based on localized stiffness changes and enables real‐time monitoring of dynamic alterations in viscoelastic properties during fibrogenesis. ABSTRACT Fibrosis is a pathological scarring process that disrupts tissue architecture, and is characterized by excessive extracellular matrix (ECM)
Vsevolod Cheburkanov   +3 more
wiley   +1 more source

Suspected Transient Ischemic Attack Related to Dysfunctional Quadricuspid Aortic Valve. [PDF]

open access: yesJ Investig Med High Impact Case Rep
Katwaroo A   +7 more
europepmc   +1 more source

Clinical Validation of a Fast MRI Method to Evaluate Brain Vascular and Parenchymal Abnormalities in Sturge‐Weber Syndrome

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Sturge‐Weber syndrome (SWS) is a rare neurocutaneous disorder associated with venous capillary malformations, atrophy, and calcifications. Longitudinal imaging is limited by risks of sedation and gadolinium exposure in children.
Scotty G. McKay   +5 more
wiley   +1 more source

Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs

open access: yesJournal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants with a morality rate that approaches 50%. Arginine has been widely studied in the field of clinical nutrition as a supplement for patients experiencing critical illness because it can be metabolized into nitric oxide, an important agent ...
Caitlin Vonderohe   +9 more
wiley   +1 more source

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