Results 81 to 90 of about 168,749 (376)

Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack.

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE Data are limited regarding the association between CYP2C19 genetic variants and clinical outcomes of patients with minor stroke or transient ischemic attack treated with clopidogrel.
Yilong Wang, Xingquan Zhao, Jinxi Lin, Hao Li, S. Johnston, Yi Lin, Yuesong Pan, Liping Liu, David Wang, Chunxue Wang, Xia Meng, Jianfeng Xu, Jianfeng Xu, Yongjun Wang   +13 more
semanticscholar   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Analysis of atherosclerotic plaque distribution in the carotid artery

Clinical Cardiology, Volume 45, Issue 12, Page 1272-1276, December 2022., 2022
Abstract Background The present study was designed to investigate the hypothesis that the outer wall at the carotid bifurcation is the most common area of atherosclerotic plaque deposition due to the low shear stress. Hypothesis We hypothesized that the most common site of arteriosclerosis in carotid arteries is different in the early and late stages ...
Shin‐Seok Yang, Shin‐Young Woo, Dong‐Ik Kim   +2 more
wiley   +1 more source

Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]

Neuroscience Research 47(2): 245-253 (2003), 2007
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury.
arxiv  

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Advanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du, Muhammad Rafiq, Hui Yuan, Xiangmin Li, Sheng Wang, Jun Wu, Jinfeng Wei, Ren‐Ke Li, Huiming Guo, Burton B Yang   +9 more
wiley   +1 more source

The brain‐before‐heart strategy for coronary artery bypass grafting in the severely atherosclerotic aorta: A single‐institution experience

Clinical Cardiology, Volume 45, Issue 12, Page 1264-1271, December 2022., 2022
Abstract Background Severe atherosclerosis of the ascending aorta (SAA) in patients undergoing surgical revascularization by coronary artery bypass grafting (CABG) is becoming an increasing problem as more elderly patients are diagnosed with coronary artery disease.
Rakan I. Nazer, Ali M. Albarrati
wiley   +1 more source

The role of transient ischemic attacks in the occurrence of cognitive impairment [PDF]

Саратовский научно-медицинский журнал, 2016
The information about cognitive impairment of patient, suffered from transient ischemic attack (TIA) is summarized on the base of Russian and foreign literature.
Maleina A.U., Kolokolov O.V., Lukina E.V.   +2 more
doaj  

Left Atrial Strain Helps Identifying the Cardioembolic Risk in Transient Ischemic Attacks Patients with Silent Paroxysmal Atrial Fibrillation

Therapeutics and Clinical Risk Management, 2022
Sergiu Florin Arnăutu,1,2,* Vlad Ioan Morariu,3,4,* Diana Aurora Arnăutu,3,4 Mirela Cleopatra Tomescu,3,4 Traian Flavius Dan,1,2 Cătălin Dragos Jianu1,2 1Neurology Department, Victor Babeș University of Medicine and ...
Arnăutu SF, Morariu VI, Arnăutu DA, Tomescu MC, Dan TF, Jianu CD   +5 more
doaj  

The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils [PDF]

Brain Research 927(2): 212-215 (2002), 2007
Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils.
arxiv  

Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

Circulation, 2017
Background: The association of genetic polymorphisms and clopidogrel efficacy in patients with ischemic stroke or transient ischemic attack (TIA) remains controversial.
Yuesong Pan, Weiqi Chen, Yun Xu, X. Yi, Yan Han, Qingwu Yang, Xin Li, Lian Huang, S. Johnston, Xingquan Zhao, Liping Liu, Qi Zhang, Guangyao Wang, Yongjun Wang, Yilong Wang   +14 more
semanticscholar   +1 more source