Results 51 to 60 of about 790,312 (266)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

On the utility of the transient climate response

Geophysical Research Letters
The Transient Climate Response (TCR) is a metric of climate sensitivity relevant to present-day climate change, but has been less well studied than the Equilibrium Climate Sensitivity. Here, we emphasize the utility of the TCR by demonstrating that temperature and radiative forcing in transient scenarios are linearly related (to a good approximation ...
Nadir Jeevanjee, D. J. Paynter, J. P. Dunne, L. T. Sentman, J. P. Krasting   +4 more
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Broadband Enhanced Structure-Preserving Reduced-Order Interconnect Macromodeling Method for Large-Scale Equation Sets of Transient Interconnect Circuit Problems

Energies, 2020
In the transient analysis of an engineering power electronics device, the order of its equivalent circuit model is excessive large. To eliminate this issue, some model order reduction (MOR) methods are proposed in the literature.
Ning Wang, Huifang Wang, Shiyou Yang
doaj   +1 more source

The transient electric responses of the cochlea

The Journal of Physiology, 1969
1. DC responses were recorded from the cochleae of pigeons, cats and guinea‐pigs. In addition to the known summating potential, transients of the same polarity were observed at the onset and termination of the tonal stimulus.2. These transients were most noticeable in the pigeon, being least in the guinea‐pig responses.3.
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

High Frequency Response of Volatile Memristors

Advanced Electronic Materials
In this theoretical study, the high‐frequency response of the electrothermal NbO2‐Mott threshold switch is focused, a real‐world electronic device, which has been proved to be relevant in several applications and is classified as a volatile memristor ...
Ioannis Messaris, Alon Ascoli, Ahmet S. Demirkol, Vasileios Ntinas, Dimitrios Prousalis, Ronald Tetzlaff   +5 more
doaj   +1 more source