Results 61 to 70 of about 6,392,109 (288)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Transient response of an erodable heat flux gauge using finite element analysis

, 2002
The transient response of an erodable ribbon element heat flux gauge has been assessed using a two-dimensional finite element (FE) analysis. Such transient heat flux gauges have previously been used for measurements in internal combustion (IC) engines ...
Buttsworth, David R., D R Buttsworth
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Testing fluvial erosion models using the transient response of bedrock rivers to tectonic forcing in the Apennines, Italy [PDF]

, 2011
The transient response of bedrock rivers to a drop in base level can be used to discriminate between competing fluvial erosion models. However, some recent studies of bedrock erosion conclude that transient river long profiles can be approximately ...
Roberts, Gerald P., G. E. Tucker, Attal, M., Roberts, G.P., D. Hobley, Cowie, P. A., Roberts, G. P., A. C. Whittaker, Whittaker, A.C., M. Attal, G. P. Roberts, P. A. Cowie, Cowie, P.A., Hobley, Daniel, Attal, M.; id_orcid, Whittaker, A. C., Tucker, G. E., Hobley, D., Tucker, G.E.   +18 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The transient electric responses of the cochlea

The Journal of Physiology, 1969
1. DC responses were recorded from the cochleae of pigeons, cats and guinea‐pigs. In addition to the known summating potential, transients of the same polarity were observed at the onset and termination of the tonal stimulus.2. These transients were most noticeable in the pigeon, being least in the guinea‐pig responses.3.
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

High Frequency Response of Volatile Memristors

Advanced Electronic Materials
In this theoretical study, the high‐frequency response of the electrothermal NbO2‐Mott threshold switch is focused, a real‐world electronic device, which has been proved to be relevant in several applications and is classified as a volatile memristor ...
Ioannis Messaris, Alon Ascoli, Ahmet S. Demirkol, Vasileios Ntinas, Dimitrios Prousalis, Ronald Tetzlaff   +5 more
doaj   +1 more source

Experimental and Theoretical Modeling of the Thermal Response of Heat Exchangers to Stochastic Flow Rate Fluctuations [PDF]

Journal of Applied Fluid Mechanics
This study investigates the transient thermal response of a double-pipe heat exchanger subjected to stochastic flow rate fluctuations through a combined experimental and numerical approach. A two-parameter model, defined by the time constant (τ) and time
M. Belmahdi, M. Guellal
doaj   +1 more source