Results 61 to 70 of about 1,668,806 (304)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Soliton response to transient trap variations

, 2008
The response of bright and dark solitons to rapid variations in an expulsive longitudinal trap is investigated. We concentrate on the effect of transient changes in the trap frequency in the form of temporal delta kicks and the hyperbolic cotangent ...
A K Kapoor, Al Khawaja U, Al Khawaja U, Carr L D, Einstein A, Hancock H, Hancock H, Khan A Atre R Panigrahi P K, P K Panigrahi, Pethick C J, Roy U, S Sree Ranjani, Strecker K E, Uncu H, Utpal Roy, Zhakarov V E, Zhakarov V E   +16 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Laboratory studies of spacecraft response to transient discharge pulses [PDF]

, 1985
The in-orbit measurement of spacecraft discharge properties was investigated. The experiments include design and fabrication of appropriate sensors and effects of spacecraft electromagnetic responses on the interpretation of the discharge data.
Adamo, R. C., Nanevicz, J. E.
core   +1 more source

THREE-DIMENSIONAL SIMULATIONS OF TRANSIENT RESPONSE OF PEM FUEL CELLS [PDF]

, 2007
Transients have utmost importance in the lifetime and performance degradation of PEM fuel cells. Recent studies show that cyclic transients can induce hygro-thermal fatigue.
Yesilyurt, Serhat, Yeşilyurt, Serhat
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transient induced global response synchronization

International Journal of Design & Nature and Ecodynamics, 2016
Synchronization has a long history in physics where it refers to the phase locking of identical oscillators. This notion has been applied in biology to such widely varying phenomena as the flashing of fireflies and the binding problem in the brain. The relationship between neural activity and the behaviour of the organism is complex and still poorly ...
openaire   +1 more source

Magnetospheric response to magnetosheath pressure pulses: A low pass filter effect [PDF]

, 2013
. We present observations from the magnetopause to the ground during periods of large amplitude, transient dynamic pressure pulses in the magnetosheath.
Archer, MO, Eastwood, JP, Horbury, TS, Weygand, JM, Yeoman, TK   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source