Results 111 to 120 of about 835,487 (342)

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Determination and Verification of Real-Time Transient Stability of Jeju System According to Increase in Renewable Energy

open access: yesEnergies
The increasing integration of resources with limited flexibility, such as solar power, electric vehicles (EVs), and other renewable energy sources, has raised significant concerns regarding power system stability.
Sungryeol Kim   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

An improved grid-forming control method with adaptive virtual impedance combining current limitation and transient stability improvement

open access: yesInternational Journal of Electrical Power & Energy Systems
The virtual impedance (VI) control method is widely used to limit fault current for grid-forming converter (GFMC). However, in this article, it is found that the VI deteriorates the transient synchronization stability of the GFMC under grid faults.
Xiaoping Zhou   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Optimal Transient Control Scheme for Grid-Forming Permanent Magnet Synchronous Generator-Based Wind Farms

open access: yesTechnologies
In this paper, an optimal transient control (OTC) scheme is proposed to improve the transient stability of the grid-forming (GFM) wind farm (WF) based on the transient stability of the WTs.
Pan Hu, Dan Liu, Kan Cao, Lai Wei
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

A multi-task transient stability assessment method adapted to topology changes using multi-graph sample and aggregate-attention network

open access: yesFrontiers in Energy Research
Transient stability assessment (TSA) plays a pivotal role in guiding power grid risk control strategies. However, it faces challenges when dealing with complex multi-graph inputs generated by pre-fault, fault occurrence, and post-fault states. Meanwhile,
Lingxiang Huang   +5 more
doaj   +1 more source

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