Results 71 to 80 of about 51,905 (293)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Synchronization of Integrate and Fire oscillators with global coupling

, 1996
In this article we study the behavior of globally coupled assemblies of a large number of Integrate and Fire oscillators with excitatory pulse-like interactions.
A. Corral, A. Corral, A. Middleton, A. Winfree, A. Winfree, B. Drossel, D. Cox, D. Dhar, D. Fisher, D. Hansel, D. Hansel, D. Hansel, D. Hansel, D. Perkel, E. Sismondo, F. Hanson, G. Ermentrout, G. Ermentrout, H. Daido, H. Daido, H. Sakaguchi, H. Smith, J. Buck, J. Buck, J. Herz, J. Hopfield, J. Neu, K. Sneppen, L. F. Abbott, L. Glass, L. Kadanoff, L. Lapique, M. Shiino, M. Tsodyks, P. Bak, P. Bak, P. Hadley, P. Matthews, P. Matthews, R. Mirollo, R. Mirollo, R. Roy, R. Stein, S. Bottani, S. Strogatz, S. Strogatz, T. Walker, U. Ernst, W. Gerstner, W. Gerstner, Y. Kuramoto, Y. Kuramoto, Y. Kuramoto, Y. Kuramoto, Y. Yamaguchi, Y. Zhang, Z. Olami   +56 more
core   +2 more sources

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Review of transient control strategies for grid-forming converters under grid voltage sag conditions

电力工程技术
As a large amount of renewable energy is integrated into the grid via power electronic converters，the power system is faced with challenges，such as reduced inertia，diminished disturbance resistance，and declining transient support capabilities.
Yuxuan LIN, Wei LI, Ling ZHU, Chong REN
doaj   +1 more source

Anticipated synchronization in coupled inertia ratchets with time-delayed feedback: a numerical study

, 2005
We investigate anticipated synchronization between two periodically driven deterministic, dissipative inertia ratchets that are able to exhibit directed transport with a finite velocity. The two ratchets interact through an unidirectional delay coupling:
A. Pikovsky, H. Linke, J. L. Mateos, José L. Mateos, Marcin Kostur, Peter Hänggi, Peter Talkner, S. Sivaprakasam   +7 more
core   +1 more source

Digital modeling of synchronous machines for transient stability studies

, 2018
This study is concerned with the development of efficient simulation methods for accurate computer representation of synchronous machines in power system transient stability studies;There are a number of models that could be used to estimate the dynamic performance of synchronous machines.
openaire   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The Effect of Excitation System on Synchronous Generator Transient Stability

IJIREEICE, 2016
The consequences of electric power outages impose studies of models that combine representations of the various components such as generators, loads, and networks in the power system. It is clear that the main role of the excitation system is supplying the field winding of the synchronous generator with the dc current for generation, as well as voltage
Mansour Babiker Idris, Ali Juma Elzubia
openaire   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Transient stability analysis and enhancement of wind farm integrated VSC-HVDC system

CSEE Journal of Power and Energy Systems
Following severe faults in wind farm integrated voltage source converter (VSC) based high-voltage direct current (HVDC) system, wind turbines (WTs) may lose synchronization with wind farm side VSC (WFVSC), which jeopardizes the reliable delivery and ...
Guanqun Li, Hua Ye, Junru Chen, Qianying Mou   +3 more
doaj   +1 more source