Results 111 to 120 of about 273,606 (300)

The Allen Telescope Array Twenty-centimeter Survey - A 690-Square-Degree, 12-Epoch Radio Dataset - I: Catalog and Long-Duration Transient Statistics

, 2010
We present the Allen Telescope Array Twenty-centimeter Survey (ATATS), a multi-epoch (12 visits), 690 square degree radio image and catalog at 1.4GHz. The survey is designed to detect rare, very bright transients as well as to verify the capabilities of ...
Amber Bauermeister, Andrew Siemion, Artyom Vitouchkine, Baars, Bower, Calvin Cheng, Carilli, Casey Law, Chat Hull, Chris Cork, Cognard, Colby Gutierrez-Kraybill, Condon, Dan Werthimer, Dave DeBoer, Dave MacMahon, David Whysong, Don Backer, Douglas Bock, Douglas Thornton, Ed Fields, Falcke, Frail, Frail, Gal-Yam, Garrett Keating, Geoffrey C. Bower, Gerry Harp, Greg Engargiola, Hallinan, Harp, Hopkins, Jack Welch, Jackson, James R. Forster, Jane Jordan, Jannuzi, Jill Tarter, Joeri van Leeuwen, John Dreher, John Lugten, John Ross, Karen Randall, Keating, Ken Smolek, Koopmans, Kozlowski, Lazio, Leo Blitz, Lynn Urry, MacMahon, Matsumura, Matt Dexter, Matt Fleming, Melvyn Wright, Mike Davis, Niklas Wadefalk, Ofek, Oren Milgrome, Peter Backus, Peter K. G. Williams, Peter McMahon, Rob Ackermann, Sault, Seth Shostak, Shannon Atkinson, Steve Croft, Susanne Jorgensen, Tamara Helfer, Tom Kilsdonk, Tom Pierson, Tucker Bradford, William C. Barott, Williams   +73 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Performance Assessment of Pneumatic-Driven Automatic Valves to Improve Pipeline Fault Detection Procedure by Fast Transient Tests

Sensors
The use of fast transients for fault detection in long transmission networks makes the generation of controlled transients crucial. In order to maximise the information that can be extracted from the measured pressure time history (pressure signal), the ...
Francesco Castellani, Caterina Capponi, Bruno Brunone, Matteo Vedovelli, Silvia Meniconi   +4 more
doaj   +1 more source

GABA_{B} Receptors Regulate Chick Retinal Calcium Waves [PDF]

, 2001
Correlated spiking activity and associated Ca²⁺ waves in the developing retina are important in determining the connectivity of the visual system. Here, we show that GABA, via GABA_{B} receptors, regulates the temporal characteristics of Ca²⁺ waves ...
Catsicas, M, Mobbs, P
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Correlation between the solar wind speed and the passage of poleward-moving auroral forms into the polar cap

Frontiers in Astronomy and Space Sciences
In 1961, Dungey suggested that magnetic reconnection occurs due to the solar-terrestrial interaction. The interplanetary magnetic field (IMF) is thought to merge with Earth’s geomagnetic field (GMF).
G. J. Fasel, L. C. Lee, E. Lake, D. Csonge, B. Yonano, O. Bradley, J. Briggs, S. H. Lee, J. Mann, F. Sigernes, D. Lorentzen   +10 more
doaj   +1 more source