Results 91 to 100 of about 275,457 (299)

Transient congenital hypothyroidism – too short to be transient

Journal of Postgraduate Medicine, 2021
Congenital hypothyroidism (CH) occurs due to thyroid dysgenesis, thyroid ectopy, and dyshormonogenesis. A proportion of CH is transient which might be due to iodine deficiency/excess or maternal antibody-mediated. Certain forms of dyshormonogenetic defects may cause transient hypothyroidism.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Noise-induced stabilization of saddle-node ghosts

New Journal of Physics, 2020
It is known that saddle-node (s-n) bifurcations leave a saddle remnant (or ghost) in the region of the phase space where the annihilation of the fixed points occurred.
Josep Sardanyés, Carles Raich, Tomás Alarcón   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Compton scattering X-ray imaging system for material detection through 3 mm aluminum shielding for potential future space application

Physics Letters B
This paper explores the application of Compton scattering imaging for the active detection of space debris at long distances and through dense metallic shielding.
Yun Li, Tong Su, Lizhi Sheng, Ruili Zhang, Pengfei Qiang, Rengzhou Zheng, Bo Wang, Yongqing Yan, Yue Li, Yalong Zhang   +9 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Anomaly Detection Method for Hydropower Units Based on KSQDC-ADEAD Under Complex Operating Conditions

Sensors
The safe and stable operation of hydropower units, as core equipment in clean energy systems, is crucial for power system security. However, anomaly detection under complex operating conditions remains a technical challenge in this field.
Tongqiang Yi, Xiaowu Zhao, Yongjie Shi, Xiangnan Jing, Wenyang Lei, Jiang Guo, Yang Meng, Zhengyu Zhang   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Influence of sinusoidal and square voltages on partial discharge inception in geometries with point-like termination

High Voltage, 2018
High-voltage equipment involves both electrical and electronic components. In electrical power network, which consists of rotating machine, power transformers and transmission lines, field enhancement at critical regions can lead to local breakdown ...
Abdelghaffar A. Abdelmalik
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source