Results 171 to 180 of about 69,545 (269)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sea-level changes modulate beach face slope in coastal upwelling zones. [PDF]

Sci Rep
Aparicio M, Lacaze L, Almar R, Alsina JM.   +3 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Functional synaptic connectivity shapes spine stability in the hippocampus. [PDF]

Nat Commun
Rais C, Wiegert JS.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Time-resolved spectroscopy of a photoactive dinuclear W/Ru complex: spectroscopic evidence for a metastable intermediate with side-on coordinated carbonyl ligand. [PDF]

Chem Sci
Borter JH, Kangsa Banik S, Kunze K, Kupfer S, Schwarzer D, Seidel WW.   +5 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons. [PDF]

iScience
Gameiro-Ros I, Tengolics AJ, Prytkova I, Kamarajan C, Pang ZP, Goate AM, Hart RP, Slesinger PA.   +7 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Susceptibility to Pitting Corrosion of AerMet 100 and 4340 Alloys for Aeronautical Applications. [PDF]

Materials (Basel)
Huerta-Zavala MS, Gaona-Tiburcio C, Nieves-Mendoza D, Jaquez-Muñoz JM, Cabral-Miramontes J, Maldonado-Bandala E, Croche-Belin R, Baltazar-Zamora MA, Landa-Ruiz L, Lopez-Leon LD, Olguin-Coca J, Almeraya-Calderon F.   +11 more
europepmc   +1 more source