Results 111 to 120 of about 5,602 (240)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Routine immunization in older adults beyond COVID-19: a qualitative analysis of experiences, perceived barriers and facilitators, and recommendations for improvement

BMC Geriatrics
Background Vaccination remains one of the most cost-effective public health strategies. However, declining immunization rates among older adults pose a growing concern. This qualitative study aimed to unveil the experiences, emotional responses, barriers
Báltica Cabieses, Alexandra Obach, Paula Madrid, Alice Blukacz, Michelle Sadler, Alejandra Carreño, Edward Mezones-Holguín   +6 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Use of Oak Hammocks by Neotropical Migrant Songbirds During Stopover in Coastal South Carolina [PDF]

, 2000
Many species of Neotropical migrant songbirds have been reported to be declining in the last few decades, and the loss and fragmentation of stopover habitat has been implicated as a potential cause of these population declines.
Somershoe, Scott Glen
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Claiming the Road: Intersectional Mobilities and Unfreedom among Migrant Farmworkers in Canada

, 2017
This study considers the travel patterns, practices and conditions that shape how migrant farmworkers circulate in rural southwestern Ontario. While migrants in Canada’s Seasonal Agricultural Worker Program (SAWP) do not exercise occupational mobility ...
Reid-Musson, Emily R.
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Frugivory and North American Migrants in a Neotropical Second-Growth Woodland

213 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1982.Bird species visitation to a single fruit source fluctuates over time due to changes in fruit density, presence of behaviorally dominant birds, and availability of alternative fruit ...
Martin, Thomas Edward
core  

Detainees within immigration removal centres: a highly unique cohort of dental patients

Journal of Health Equity
In Britain, immigration detention is the system used for detaining irregular migrants in a secure setting, known as an immigration removal centre (IRC). Detainees include: foreign national ex-offenders who have completed a prison sentence in Britain, and
Bhaven Modha
doaj   +1 more source