Results 31 to 40 of about 5,174 (276)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time from arrival in Chile to tuberculosis diagnosis in migrants treated at primary care centers in two Metropolitan Region municipalities, Chile

Medwave
Introduction In Chile, the number of migrants affected by tuberculosis has experienced a significant increase from 7.1% in 2014 to 29.7% in 2023, ranking as the first group at risk. The objective was to estimate the time to diagnosis of tuberculosis from
Alejandra Puga-Arriagada, Jhonatan Castro Horna, Marinella Mazzei Pimentel, Gabriel Cavada Chacón, Guillermo Sequera, Javiera Varela-Torres, Olivia Horna-Campos   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Crescimento urbano e doença: a esquistossomose no município de São Paulo (Brasil) Urban growth and disease: schistosomiasis in the municipality of S. Paulo (Brazil)

Revista de Saúde Pública, 1985
Procurou-se mostrar o papel da evolução urbana da cidade de São Paulo (Brasil), no surgimento das condições propícias para o estabelecimento da transmissão da esquistossomose que no Sudeste brasileiro é usualmente considerada como conseqüência do ...
Luiz Jacintho da Silva
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Pain as a Symptom of Mental Health Conditions Among Undocumented Migrants in France: Results From a Cross-Sectional Study

International Journal of Public Health
ObjectivesThis study aimed to explore the associations between mental health status and experienced pain among undocumented migrants (UMs) in France.MethodsWe used data from the multicentric cross-sectional “Premier Pas” study conducted in the Parisian ...
Sohela Moussaoui, Sohela Moussaoui, Sohela Moussaoui, Nicolas Vignier, Nicolas Vignier, Nicolas Vignier, Stephanie Guillaume, Florence Jusot, Florence Jusot, Antoine Marsaudon, Jérôme Wittwer, Jérôme Wittwer, Paul Dourgnon   +12 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Life and health status of older migrants with hypertension in China: results from the 2018 China health and retirement longitudinal study

BMC Public Health
Background In China, internal migrants are a vulnerable population due to the challenges of the health and social system. With the increase of population aging, older migrants have an increasing risk of developing chronic conditions.
Ruilong Wang, Ailin Zhong, Jingyi Ye, Yuan Liu, Lili Sun, Jingsheng Chen, Guanyang Zou   +6 more
doaj   +1 more source

Use of health services among international migrant children – a systematic review

Globalization and Health, 2018
Background Migrant children have specific health needs, and may face difficulties in accessing health care, but not enough is known about their health service use.
Niina Markkula, Baltica Cabieses, Venla Lehti, Eleonora Uphoff, Sofia Astorga, Francisca Stutzin   +5 more
doaj   +1 more source